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  Jamestown Canyon Virus Meningoencephalitis: A Case Report

  Amy Ishbia, Hannah Guide, Matthew Sierra, and Jonathan Doty

  Publication Date: 5-9-2024

  Jamestown Canyon virus is a rare mosquito-borne orthobunyavirus that typically is asymptomatic or causes mild symptoms. However, it can rarely cause severe neuroinvasive disease [2,5]. The primary hosts include white-tailed deer, although moose, elk, and bison can also be hosts [2].

  Typically, cases are seen between April and September, with a bimodal distribution peaking in spring and late summer [2].

  Number of cases in the U.S. in 2024: 16 total cases, 11 neuroinvasive [1]. Number of cases in the U.S. between 2011-2023: 308, with 10 deaths, 206 neuroinvasive. One case was reported from Alpena, MI, where our patient resided [1].

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  Varicella-Zoster Encephalitis Presenting with Trigeminal Neuralgia, Complicated by Vasculopathy

  Amy Ishbia, Kathy Ross, Dillon Yaldo, Jacob Conroy, and Andrea Stoner

  Publication Date: 5-9-2024

  VZV is a herpesvirus that causes chickenpox before laying dormant and having the potential to reactivate to cause myelitis, encephalitis, or vasculopathy.

  Encephalitis occurs in less than 0.1% of cases; however accounts for 90% of neurologic complications from VZV.

  Vasculopathy is a rare complication of VZV encephalitis characterized by vessel wall damage and transmural inflammation with multinucleated giant cells and/or epithelioid macrophages.

  Vasculopathy has significant morbidity/mortality due to ischemic/hemorrhagic stroke, spinal cord infarction, temporal artery inflammation, ischemic cranial neuropathies and cerebral venous thrombosis.

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  Anti-Yo Positive Paraneoplastic Cerebellar Degeneration: A Case of Discovering Fallopian Tube Cancer From Neurological Symptoms

  Sydney Jacobs, Alaina Skotak, and Inna Sta Maria

  Publication Date: 5-9-2024

  Paraneoplastic syndromes are rare neurological disorders associated with cancer at distant tumor sites. Prevalence is ~1-3% of all cancers, with an estimated 17,099 cases in the US in 2021.

  Paraneoplastic cerebellar degeneration (PCD) is one subtype, primarily associated with gynecological and breast cancer, especially in women older than 60.2

  Can cause significant functional impairment (e.g. abrupt onset truncal ataxia, room-spinning dizziness, dysarthria, and diplopia).

  Neurological symptoms often precede cancer diagnosis.

  Pathophysiology of PCD: Tumor-induced autoimmunity against cerebellar antigens.4 About 30 types of antibodies, one being anti-Yo antibody (or Purkinje cell cytoplasmic antibody type 1, (PCA-1)) acting on human cerebellar degeneration-related protein.

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  Seeing Double An atypical presentation of RCVS

  Lauren Kassab, Alexander Ismail, and Jonathan Doty

  Publication Date: 5-9-2024

  Reversible cerebral vasoconstriction syndrome (RCVS) is a syndrome characterized by reversible, multifocal narrowing of the cerebral arteries and a thunderclap headache (reaching a peak intensity within one minute). A less severe headache, or lack thereof, is rare (1). Additional neurologic symptoms are typically dependent on the sequelae of focal intracranial stenosis, including ischemia, PRES, and IPH. Common precipitants are cannabis, SSRIs, alcohol, cocaine, and eclampsia. Depending on the inciting cause, presentations can also widely vary over a course of months - years. Diagnosis can be pervasive, as noninvasive vascular imaging has an 80% sensitivity (2). Definitive diagnosis is made with angiogram, with vasoconstriction in at least two vessels and resolution in three months, as well as negative serology and CSF markers for vasculitis. Treatment involves identifying and reversing the offending agent, and in some cases calcium channel blockers.

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  Responsive Neurostimulation (RNS) of the Centromedian Nucleus (CMN) of the Thalamus for the Treatment of Drug Resistant Idiopathic Generalized Epilepsy (IGE)

  Angelique Manasseh, Hannah Guider, Brooklynn Bondy, Sanjay Patra, David Burdette, M. Ayman Haykal, Nour Baki, Ashleigh Terrell, Michael Staudt, Christopher Parres, and Andrew Zillgitt

  Publication Date: 5-9-2024

  Idiopathic generalized epilepsy (IGE) accounts for nearly 1/3 of all epilepsies.

  Approximately 20-30% of people with IGE are refractory to adequate anti-seizure medication trials.

  RNS implantation is a unique closed-loop neuromodulation therapy, and case reports as well as case series have demonstrated improved seizure control in patients with drug resistant IGE.

  More recently, targeting the centromedian nucleus of the thalamus with RNS has been explored as a potential surgical treatment option for patients with drug resistant IGE.

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  Applications of Minirail External Fixator in Arthrodesis Foot Surgery for the High-Risk Patient Population: A Case Series

  Reema Naman

  Publication Date: 5-9-2024

  Since the inception of external fixation, there have been many modifications to the utilization of the devices, including the size. The minirail external fixator has evolved since the usage for bracymetatarsia into more complex devices. In the podiatric patient population, there are many comorbidities encountered such as diabetes, idiopathic neuropathy, and smoking. In the diabetic neuropathic population the purpose of use of the minirail external fixator was to provide additional stability as a mini-superconstruct as per Sammarco principles. An additional benefit of the fixator is the option of removing the pins if there are any signs of infection. The purpose of this case series is to exhibit the benefit and myriad of uses of the minirail external fixator in high-risk patient population.

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  Complex Removal of Heterogenous Soft Tissue Mass in Patient with Prior History of Malignancy

  Yumna Siddiqui and Randy Semma

  Publication Date: 5-9-2024

  There is a variety of pathologies seen in the foot and ankle. One of the more challenging pathologies involves the ability to obtain the correct diagnosis and therapeutic treatment for a soft tissue mass of unknown etiology. With both benign and malignant tumors found in the lower extremities, most malignancy presenting in the foot and ankle is primary in nature. However, in patients with history of malignancy elsewhere in the body, a possible secondary metastatic tumor should always be a differential. Therefore, early diagnosis and treatment is of upmost importance. We present a case study of a patient with prior history of uterine cancer, presenting with an enlarging heterogenous soft tissue mass on her ankle.

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  Varicella-Zoster Encephalitis Presenting with Trigeminal Neuralgia, Complicated by Vasculopathy

  Amy Ishbia, Katherine Ross, Dillon Yaldo, Jacob Conroy, and Andrea Stoner

  Publication Date: 5-4-2023

  VZV is a herpesvirus that causes chickenpox before laying dormant and having the potential to reactivate to cause myelitis, encephalitis, or vasculopathy [1,4]. ▪ Encephalitis occurs in less than 0.1% of cases; however accounts for 90% of neurologic complications from VZV [2].

  Vasculopathy is a rare complication of VZV encephalitis characterized by vessel wall damage and transmural inflammation with multinucleated giant cells and/or epithelioid macrophages.

  Vasculopathy has significant morbidity/mortality due to ischemic/hemorrhagic stroke, spinal cord infarction, temporal artery inflammation, ischemic cranial neuropathies and cerebral venous thrombosis [2].

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  Anti-Yo Positive Paraneoplastic Cerebellar Degeneration: A Case of Discovering Fallopian Tube Cancer From Neurological Symptoms

  Sydney Jacobs, Alaina Skotak, and Inna Sta Maria

  Publication Date: 5-4-2023

  Paraneoplastic syndromes are rare neurological disorders associated with cancer at distant tumor sites. Prevalence is ~1-3% of all cancers, with an estimated 17,099 cases in the US in 2021.

  ▪ Paraneoplastic cerebellar degeneration (PCD) is one subtype, primarily associated with gynecological and breast cancer, especially in women older than 60.2

  ▪ Can cause significant functional impairment (e.g. abrupt onset truncal ataxia, room-spinning dizziness, dysarthria, and diplopia).

  ▪ Neurological symptoms often precede cancer diagnosis.

  ▪ Pathophysiology of PCD: Tumor-induced autoimmunity against cerebellar antigens.4 About 30 types of antibodies, one being anti-Yo antibody (or Purkinje cell cytoplasmic antibody type 1, (PCA-1)) acting on human cerebellar degeneration-related protein.

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  Seeing Double An Atypical Presentation of RCVS

  Lauren Kassab, Alex Ismail, and Jonathan Doty

  Publication Date: 5-4-2023

  Reversible cerebral vasoconstriction syndrome (RCVS) is a syndrome characterized by reversible, multifocal narrowing of the cerebral arteries and a thunderclap headache (reaching a peak intensity within one minute). A less severe headache, or lack thereof, is rare (1). Additional neurologic symptoms are typically dependent on the sequelae of focal intracranial stenosis, including ischemia, PRES, and IPH. Common precipitants are cannabis, SSRIs, alcohol, cocaine, and eclampsia. Depending on the inciting cause, presentations can also widely vary over a course of months - years. Diagnosis can be pervasive, as noninvasive vascular imaging has an 80% sensitivity (2). Definitive diagnosis is made with angiogram, with vasoconstriction in at least two vessels and resolution in three months, as well as negative serology and CSF markers for vasculitis. Treatment involves identifying and reversing the offending agent, and in some cases calcium channel blockers.

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  Evaluation of peri-operative antibiotic prophylaxis in patients undergoing total joint hip or knee arthroplasty

  Heidi Klotz, Lauren Kassab, Muddasser Saiyed-Javed, Sandra Hartnagle, and Sapna Shah

  Publication Date: 12-6-2023

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  Responsive Neurostimulation (RNS) of the Centromedian Nucleus (CMN) of the Thalamus for the Treatment of Drug Resistant Idiopathic Generalized Epilepsy (IGE)

  Angelique Manasseh, Hannah Guider, Brooklynn Bondy, Sanjay Patra, David Burdette, Ayman Haykal, Nour Baki, Ashleigh Terrell, Michael Staudt, Christopher Parres, and Andrew Zillgitt

  Publication Date: 5-4-2023

  Idiopathic generalized epilepsy (IGE) accounts for nearly 1/3 of all epilepsies1

  ▪ Approximately 20-30% of people with IGE are refractory to adequate anti-seizure medication trials1

  ▪ RNS implantation is a unique closed-loop neuromodulation therapy, and case reports as well as case series have demonstrated improved seizure control in patients with drug resistant IGE1

  ▪ More recently, targeting the centromedian nucleus of the thalamus with RNS has been explored as a potential surgical treatment option for patients with drug resistant IGE

• 

  Applications of Minirail External Fixator in Arthrodesis Foot Surgery for the High-Risk Patient Population A Case Series

  Reema Naman and Randy Semma

  Publication Date: 5-4-2023

  Since the inception of external fixation, there have been many modifications to the utilization of the devices, including the size. The minirail external fixator has evolved since the usage for bracymetatarsia into more complex devices. In the podiatric patient population, there are many comorbidities encountered such as diabetes, idiopathic neuropathy, and smoking. In the diabetic neuropathic population the purpose of use of the minirail external fixator was to provide additional stability as a mini-superconstruct as per Sammarco principles. An additional benefit of the fixator is the option of removing the pins if there are any signs of infection. The purpose of this case series is to exhibit the benefit and myriad of uses of the minirail external fixator in high-risk patient population.

• 

  Complex Removal of Heterogenous Soft Tissue Mass in Patient with Prior History of Malignancy

  Yumna Siddiqui and Randy Semma

  Publication Date: 5-4-2023

  There is a variety of pathologies seen in the foot and ankle. One of the more challenging pathologies involves the ability to obtain the correct diagnosis and therapeutic treatment for a soft tissue mass of unknown etiology. With both benign and malignant tumors found in the lower extremities, most malignancy presenting in the foot and ankle is primary in nature. However, in patients with history of malignancy elsewhere in the body, a possible secondary metastatic tumor should always be a differential. Therefore, early diagnosis and treatment is of upmost importance. We present a case study of a patient with prior history of uterine cancer, presenting with an enlarging heterogenous soft tissue mass on her ankle.

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  A Rare Case of Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy

  Jonathan Doty and Jonathan Fellows

  Publication Date: 5-2022

  • Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is a rare autoimmune inflammatory disorder typically manifesting as a meningoencephalomyelitis first identified in 20161 . • Awareness of the clinical manifestations and hallmark radiographic findings is important for appropriate diagnostic testing and treatment.

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  Inflammatory Myopathy and Myasthenia Gravis Overlap Syndrome

  Brandon Vieder, Nick Olen, William Boudouris, and Robert Pierce

  Publication Date: 5-2022

  • We present the case of a rare, complex process of overlap between Myasthenia Gravis and Inflammatory Myositis. • Less than 50 cases have been reported, and do not respond as readily to typical treatments

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  Isolated Bilateral Cerebellar Restriction Diffusion: An Atypical Presentation of Wernicke’s Encephalopathy

  Diana Zaituna and Angelique Manasseh

  Publication Date: 5-2022

  • Wernicke encephalopathy is a neurologic complication of thiamine (vitamin B1) deficiency • Familiarity with clinical presentation and MRI findings are important for rapid diagnosis • Treatment is with emergent thiamine supplementation to prevent morbidity (i.e. Korsakoff syndrome) and mortality1 • We present a case of Wernicke’s encephalopathy with the rare MRI brain finding of isolated cerebellar diffusion restriction, which has only been seen in one other case report, per our extensive literature review