Anti-Yo Positive Paraneoplastic Cerebellar Degeneration: A Case of Discovering Fallopian Tube Cancer From Neurological Symptoms

Files

Authors

Sydney Jacobs, Corewell Health Resident
Alaina Skotak, Corewell Health
Inna Sta Maria, Corewell Health Resident

Description

Paraneoplastic syndromes are rare neurological disorders associated with cancer at distant tumor sites. Prevalence is ~1-3% of all cancers, with an estimated 17,099 cases in the US in 2021.

Paraneoplastic cerebellar degeneration (PCD) is one subtype, primarily associated with gynecological and breast cancer, especially in women older than 60.2

Can cause significant functional impairment (e.g. abrupt onset truncal ataxia, room-spinning dizziness, dysarthria, and diplopia).

Neurological symptoms often precede cancer diagnosis.

Pathophysiology of PCD: Tumor-induced autoimmunity against cerebellar antigens.4 About 30 types of antibodies, one being anti-Yo antibody (or Purkinje cell cytoplasmic antibody type 1, (PCA-1)) acting on human cerebellar degeneration-related protein.

Publication Date

5-9-2024

Disciplines

Internal Medicine | Neurology

Recommended Citation

Jacobs S, Skotak A, Maria IS. Anti-Yo positive paraneoplastic cerebellar degeneration: a case of discovering fallopian tube cancer from neurological symptoms. Presented at Corewell Health Hospital Farmington Hills 2024 Alvin Yarrows Research Day; 2024 May 9; Farmington Hills, MI.

Comments

2024 Alvin Yarrows Research Day at Corewell Health Hospital Farmington Hills, Farmington Hills, MI, May 9, 2024.