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Description
Paraneoplastic syndromes are rare neurological disorders associated with cancer at distant tumor sites. Prevalence is ~1-3% of all cancers, with an estimated 17,099 cases in the US in 2021.
▪ Paraneoplastic cerebellar degeneration (PCD) is one subtype, primarily associated with gynecological and breast cancer, especially in women older than 60.2
▪ Can cause significant functional impairment (e.g. abrupt onset truncal ataxia, room-spinning dizziness, dysarthria, and diplopia).
▪ Neurological symptoms often precede cancer diagnosis.
▪ Pathophysiology of PCD: Tumor-induced autoimmunity against cerebellar antigens.4 About 30 types of antibodies, one being anti-Yo antibody (or Purkinje cell cytoplasmic antibody type 1, (PCA-1)) acting on human cerebellar degeneration-related protein.
Publication Date
5-4-2023
Disciplines
Internal Medicine | Neurology
Recommended Citation
Jacobs S, Skotak A, Maria I. Anti-Yo positive paraneoplastic cerebellar degeneration: a case of discovering fallopian tube cancer from neurological symptoms. Presented at Beaumont Hospital Farmington Hills 2023 Alvin Yarrows Research Day; 2023 May 4; Farmington Hills, MI.
Comments
2023 Alvin Yarrows Research Day at Beaumont Hospital Farmington Hills, Farmington Hills, MI, May 4, 2023.