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  Relationship Between Obesity and Triple-Negative Breast Cancer: A Retrospective Study

  Mariam Aoun, Anna Jahshan, Nayana Dekhne, and Varna Taranikanti

  Publication Date: 5-2-2022

  INTRODUCTION
  Several research studies have identified a positive correlation between obesity and specific receptor statuses in breast cancer, including ER-positive, PR-positive, and HER2-positive breast cancers. However, triple-negative breast cancer (TNBC) in particular has not been studied in relation to body mass index (BMI), which suggests that an analysis of triple-negative breast cancer and its relation to obesity is warranted. This study aims to analyze the association between triple-negative breast cancer and BMI through a retrospective analysis in order to further guide patient counseling about TNBC risk factors.

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  Comparing Radiological characteristics of Neck Pain in Younger versus Older Patients: A retrospective analysis

  Jnana Aditya Challa, Abdul Majid Khan, and Varna Taranikanti

  Publication Date: 5-2-2022

  INTRODUCTION
  Neck pain commonly occurs during the fifth or sixth decade of life due to degenerative changes in the spine. With increased usage of digital technology from a very young age we hypothesized an earlier age of onset of these degenerative changes. There have been no recent epidemiologic studies that investigated difference in radiological changes seen in older versus younger patients presenting with neck pain. Hence, this study is undertaken to analyze the variability in radiological changes seen in the cervical vertebrae between older (>50) versus younger (≤50) patients presenting with the chief complaint of neck pain.

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  ERAS vs Non-ERAS: A Hospital Performance Metrics Comparsion in Patients Undergoing Spinal Fusion

  Richard W. Easton, Gregory Smith, Matthew Lipphardt, Nai-Wei Chen, Pestano Cecile, Hermeli Mateo, Austin Ahlgren, Brady Vibert, Andrew Sagante, and Susan Vander Beek

  Publication Date: 5-2022

  Hospital metrics are measures used to evaluate surgical quality. The goal is to improve standards of care (SOC). Hospital performance is made publicly available and has reimbursement ramifications.

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  Prospective Qualitative Analysis of Minimally Invasive Repair of Pectus Excavatum

  Timothy Elton, Diane Studzinski, Robert S. Morden, and Pavan Brahmamdam

  Publication Date: 5-2-2022

  INTRODUCTION
  Pectus Excavatum is the most common chest wall deformity and is frequently corrected with the Nuss procedure. Although this procedure has existed for several decades, new strategies are being adapted to reduce complications and improve efficiency. The aim of this study is to perform a qualitative review of the patient experience after minimally invasive repair of Pectus Excavatum.

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  Prehospital Use of Ketamine in the Pediatric Population

  Ashima Goyal, Revelle Gappy, Remle Crowe, John Frawley, Nai-Wei Chen, and Robert Swor

  Publication Date: 1-2022

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  Effect of SARS-COV2 on Adolescent PHQ-9 Screening Result

  Anisah Hashmi, Aimee Pollak, Leah Ludwig, Kerry P. Mychaliska, Mara Rubenstein, Olufunke Adeyemo, Stacey Shubeck, Liu Qu, and Mary Coffey

  Publication Date: 5-2-2022

  INTRODUCTION
  The SARS-COV2 pandemic created numerous stressors for adolescents including financial insecurities, family illness or death, home schooling, discontinuation of group activities, and decreased peer interaction. Prior studies have shown an increased risk for self-reported depression symptoms in pediatric patients following traumatic events. The purpose of this study is to compare rates of newly diagnosed depression in adolescents and self-reported depression symptoms prior to and during the pandemic.

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  Relationship Between Smoking and Triple-Negative Breast Cancer: A Retrospective Analysis

  Anna Jahshan, Mariam Aoun, Nayana Dekhne, and Varna Taranikanti

  Publication Date: 5-2-2022

  INTRODUCTION
  Breast cancer is currently the most common cancer by incidence among women in the United States with high mortality. Compared to other specific types, triple-negative breast cancer (TNBC) is considered to be an aggressive cancer with poor prognosis. Hence, it is important to study the risk factors associated with it. Smoking has been implicated in many cancers, including breast cancer. However, there is no evidence in literature that has shown a relationship between smoking and a specific type of breast cancer. The goal of this study is to analyze the relationship between smoking and TNBC so that we may improve the understanding of the risk factors related to this type of breast cancer.

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  Clearance of the Cervical Spine in Obtunded Pediatric Blunt Trauma Patients: Quality Assessment of an Existing Clearance Pathway

  Rachel Kalthoff, Elizabeth Boudiab, Diane Studzinski, Nathan Novotny, Pavan Brahmamdam, and Begum Akay

  Publication Date: 5-2-2022

  INTRODUCTION
  Obtunded patients following blunt trauma need clearance of the cervical spine (c-spine) that cannot depend on a clinical exam. Our center’s current pediatric c-spine evaluation pathway includes both Computed Tomography (CT) and Magnetic Resonance Imaging (MRI). The objective of this study was to review our use of both CT and MRI for obtunded pediatric trauma patients to assess the quality of our pathway and utility of MRI.

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  Perioperative Antibiotic Use in Neonatal Surgery

  Lior Kopel, Patrick Karabon, Nathan Novotny, Begum Akay, and Pavan Brahmamdam

  Publication Date: 5-2-2022

  INTRODUCTION
  The ideal duration of perioperative antibiotic prophylaxis to prevent surgical site infection (SSI) in neonates is undetermined. The aim of this study is to evaluate the association between the duration of perioperative antibiotics and SSIs in the neonatal surgical population.

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  Radioactive iodine therapy (RAIT) in N1 papillary thyroid cancer: Are we overtreating?

  Elizabeth Odil, Jordan Reilly, Fionna Sun, Diane Studzinski, Rose E. Callahan, and Sapna Nagar

  Publication Date: 4-28-2022

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  Functional Lung Segmentation from Computed Tomography Images using Deep Learning

  Duyen M. Quach, Evan Porter, and Thomas M. Guerrero

  Publication Date: 5-2-2022

  INTRODUCTION
  Functional avoidance treatment planning allows radiation oncologists to intentionally minimize radiation dose to higher-functioning lung areas while favoring radiation dose towards lower-functioning regions. This treatment planning method has been shown to reduce pulmonary toxicity for patients receiving radiation therapy. Functional lung information, traditionally ventilation or perfusion SPECT scans, is required to plan for functional avoidance.

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  Acute Post-Operative Pain Following Anterior Cruciate Ligament Reconstruction: A comparison of Patellar Tendon vs Hamstring Autograft

  Dustin J Randall, Denise Koueiter, Brandon Luczak, and Kyle Anderson

  Publication Date: 5-2-2022

  INTRODUCTION
  Choosing between a bone-patellar tendon-bone (BTB) or hamstring tendon (HS) graft for primary anterior cruciate ligament (ACL) reconstruction has long been a topic of debate and discrepancy in orthopaedic literature, with many factors contributing to the decision process. The purpose of this study is to analyze acute post-operative pain scores of patients who underwent ACL reconstruction and compare the results between BTB autograft and the HS autograft techniques.

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  Spontaneous Pneumomediastinum in Children is Not Associated with Esophageal Perforation

  Kevin Roby, Catherine Barkach, Diane Studzinski, Nathan Novotny, Begum Akay, and Pavan Brahmamdam

  Publication Date: 5-2-2022

  INTRODUCTION
  We hypothesize that esophageal perforation is not a common etiology for spontaneous pneumomediastinum (SPM), and that SPM is a self-limited disease not requiring routine admission.

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  Urinary cytokines as potential biomarkers of mild cognitive impairment and Alzheimer’s disease: a pilot study

  Nazia Saiyed Saiyed, Ali Yilmaz, Sangeetha Vishweswariah, Sarah Bartolone, Tammy Osentoski, Stacey Ruff, Amita Pai, Michael Maddens, Khaled Imam, and Stewart F. Graham

  Publication Date: 10-21-2022

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  Therapeutic efficacy of zinc in the treatment of COVID-19 patients: A systematic review

  Olivia Schimmel and Varna Taranikanti

  Publication Date: 5-2-2022

  INTRODUCTION
  Novel therapeutic interventions are of utmost importance to alleviate the clinical symptoms caused by inflammation in COVID-19 patients. The beneficial role of zinc has been suggested due to its ability to mitigate the effects of the inflammatory cascade. Hence it has been hypothesized that patients with zinc deficiency may benefit symptomatically from treatment with zinc. The primary goal of this systematic review of randomized controlled trials conducted between February and March 2021 is to determine the efficacy of zinc as a treatment for COVID-19 infection.

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  What is the Incidence of QT Prolongation and Life-Threatening Arrhythmia Following IV Methadone Administration in Patients Undergoing Lumbar Fusion?

  Gregory Smith, Richard W. Easton, Kuldeep Shah, Daniel Silvasi, Matthew Lipphardt, Julie George, Shengchuan Dai, Brian Williamson, Brady Vibert, Bradley Ahlgren, and Nicholas Papakonstantinou

  Publication Date: 5-2022

  Postoperative analgesia is a significant challenge following major spine surgery. Utilizing a combination of opioid and non-opioid medications, optimizing their analgesic benefits while decreasing unwanted side effects, has been an effective multi-modal strategy in an Enhanced Recovery After Surgery (ERAS) protocol.

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  Cardiac Arrest Patient Length of Stay and Survival in Michigan Hospitals

  Jaemin Song, David A. Berger, James H. Paxton, Joseph B. Miller, Joshua Reynolds, Nai-Wei Chen, and Robert Swor

  Publication Date: 5-2-2022

  INTRODUCTION
  Current guidelines recommend deferring prognostic decisions for at least 72 hours following admission after Out of Hospital cardiac arrest (OHCA). Most non-survivors experience withdrawal of life-sustaining therapy (WLST), and early WLST may adversely impact survival. We sought to characterize the hospital length of stay (LOS) and timing of Do Not Resuscitate (DNR) orders (as surrogates for WLST) to assess their relationship to survival following cardiac arrest.

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  Association of Gut Metabolomic Biomarkers with Sleeve Gastrectomy Weight-Loss Outcomes

  Pamela Spicer, Wendy Miller, Kathryn Ziegler, and Stewart Graham

  Publication Date: 5-2-2022

  INTRODUCTION
  Obesity is a prevalent health challenge with high morbidity and many associated chronic diseases. Sleeve gastrectomy is currently the predominant intervention for obesity. However, weight loss results are variable. The mechanisms and factors influencing this variability are not well understood. We evaluated the correlation of metabolomic biomarkers with weight-loss.

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  Development of A Deep Neural Network for Synthesis of Non-Contrast Cranial T1-Weighted Magnetic Resonance Imaging

  Agueda M. Taylor, Evan Porter, and Thomas Guerrero

  Publication Date: 5-2-2022

  INTRODUCTION
  Although 122 out of 1000 people in the US have MRI’s done each year, there are over 4 million with contraindications that subsequently forgo the diagnostic benefits. Studies in recent years have implemented artificial intelligence (AI) algorithms such as deep neural networks (DNN) for production of synthetic medical imaging. The goals of this project are to develop a DNN, specifically a Generative Adversarial Network (GAN) that will predict synthetic Cranial T1 Weighted MRI from non-contrast CT, and to evaluate the model quality.

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  Ventricular assist device association in improving outcomes in patients resuscitated from out of hospital cardiac arrest

  Julie Tram, Andrew Pressman, Nai-Wei Chen, David Berger, Joseph Miller, Robert Welch, Joshua Reynolds, James Pribble, Robert Swor, and CARES Surveillance Group

  Publication Date: 5-2-2022

  INTRODUCTION
  There has been continued debate on the efficacy of ventricular assist devices (VAD) on improving survival outcomes in post cardiac arrest patients.
  The objective of this study is to assess whether the use of VAD is associated with improved survival outcome in patients resuscitated from out-of-hospital cardiac arrest in Michigan.

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  Longitudinal metabolomics in the brain of mouse models with mild and severe traumatic brain injury

  Ali Yilmaz, Sigal Liraz Zaltsman, Esther Shohami, Juozas Gordevicius, Jack E. Sherman, Ray Bahado-Singh, and Stewart F. Graham

  Publication Date: 9-16-2022