Phenotype characterization of genetic murine mouse models of developmental dysplasia of the hip (DDH)

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Authors

Stephanie Mrowczynski, Oakland University William Beaumont School of Medicine Student
Kevin Baker
Michael Newton, Beaumont Health

Description

Developmental dysplasia of the hip (DDH) is a congenital hip alteration that changes the “ball in socket” movement of the leg inside the pelvis. Genome-wide association studies have identified CX3CR1 polymorphisms associated with increased risk of Developmental Dysplasia of the Hip. Mouse models of CX3CR1 knock-out (KO) mice show unilateral, bony discrepancies between the femur head and acetabulum in comparison to wild-type (WT) mice, as well as gait impairment similar to that of humans with osteoarthritis (which develops in DDH patients later in life). The primary goal of this project is to assess joint congruity in a CX3CR1 KO model of unilateral developmental dysplasia of the hip and control populations via microcomputed tomography. The secondary goal is to evaluate bone and joint characteristics in CX3CR1 KO model of unilateral developmental dysplasia of the hip and control populations via microcomputed

Publication Date

5-2023

Keywords

dysplasia of the hip

Disciplines

Orthopedics

Recommended Citation

Mrowczynski S, Baker K, Newton M. Phenotype characterization of genetic murine mouse models of developmental dysplasia of the hip (DDH). Poster presented at: Oakland University William Beaumont School of Medicine Embark Capstone Colloquium; 2023 May; Rochester Hills, MI.

Comments

The Embark Capstone Colloquium at the Oakland University William Beaumont School of Medicine, Rochester Hills, MI, May, 2023