Association of Baseline Magnetic Resonance Imaging Prostate Imaging Reporting and Data System Score With Prostate Cancer Active Surveillance Early Biopsy Reclassification: Data From the Michigan Urological Surgery Improvement Collaborative (MUSIC).

Authors

Kiran R. Nandalur, Corewell Health
Chen Shen, Corewell Health
Lili Zhao, Corewell Health
Sayf Al-Katib, Corewell Health
Joseph Lee, Corewell Health Resident
Brian Seifman, Corewell Health
Hong Ye, Corewell Health
Thomas Quinn, Corewell Health
Sirisha Nandalur, Corewell Health
David Gangwish, Corewell Health Resident
Abhay Dhaliwal, Corewell Health
Jason Hafron, Corewell Health

Document Type

Article

Publication Date

10-2024

Publication Title

The Journal of urology

Abstract

PURPOSE: The purpose of our study was to evaluate the association of baseline MRI Prostate Imaging Reporting and Data System (PI-RADS) score with biopsy reclassification in a multicenter active surveillance (AS) cohort.

MATERIALS AND METHODS: We identified men in the Michigan Urological Surgery Improvement Collaborative registry (46 hospital-based/academic/private practice urology groups) with National Comprehensive Cancer Network (NCCN) low-risk and favorable intermediate-risk prostate cancer who underwent MRI within 6 months before or after initial biopsy and enrolled in AS from June 2016 to January 2021. The primary objective was to determine the association of baseline MRI PI-RADS score (≥4 lesion) with reclassification to high-grade prostate cancer (≥grade group 3) on surveillance biopsy. Multivariable Cox proportional hazards regression models were constructed and adjusted for pathologic, MRI, and clinical/biopsy factors, with landmark time of 6 months from diagnostic biopsy. We included an interaction term between PI-RADS score and NCCN group in the Cox model.

RESULTS: A total of 1491 men were included with median age 64 years (IQR: 59-69) with median follow-up 11.0 months (IQR: 6.0-23.0) after landmark. Baseline PI-RADS ≥ 4 lesion was associated with an increased hazard of biopsy reclassification (HR: 2.3 [95% CI: 1.6-3.2],

CONCLUSIONS: In this multicenter cohort study of real-world data, baseline MRI PI-RADS score was significantly associated with early biopsy reclassification in men undergoing AS with NCCN low- or favorable intermediate-risk prostate cancer.

Volume

212

Issue

4

First Page

571

Last Page

579

Recommended Citation

Nandalur KR, Shen C, Zhao L, Al-Katib S, Lee J, Seifman B, et al [Ye H, Quinn T, Nandalur S, Gangwish D, Dhaliwal A, Hafron J] Association of baseline magnetic resonance imaging prostate imaging reporting and data system score with prostate cancer active surveillance early biopsy reclassification: data from the Michigan urological surgery improvement collaborative (music). J Urol. 2024 Oct;212(4):571-579. doi: 10.1097/JU.0000000000004117. PMID: 38917450.

DOI

10.1097/JU.0000000000004117

ISSN

1527-3792

PubMed ID

38917450