Linear Energy Transfer Incorporated Spot-Scanning Proton Arc Therapy Optimization: A Feasibility Study.

Authors

Xiaoqiang Li, Beaumont Health
Xuanfeng Ding, Beaumont Health
Weili Zheng, Beaumont Health
Gang Liu, Beaumont Health
Guillaume Janssens
Kevin Souris
Ana M Barragán-Montero
Di Yan
Craig Stevens
Peyman Kabolizadeh

Document Type

Article

Publication Date

6-12-2021

Publication Title

Frontiers in oncology

Abstract

Purpose: To integrate dose-averaged linear energy transfer (LET

Methods: An open-source proton planning platform (OpenREGGUI) has been modified to incorporate LET

Results: With similar dose distributions, the efficacy of spatially optimizing LET

Conclusion: This work demonstrates the feasibility and significant advantages of using SPArc for LET

Volume

11

First Page

698537

Recommended Citation

Li X, Ding X, Zheng W, Liu G, Janssens G, Souris K, Barragán-Montero AM, Yan D, Stevens C, Kabolizadeh P. Linear Energy Transfer Incorporated Spot-Scanning Proton Arc Therapy Optimization: A Feasibility Study. Front Oncol. 2021 Jul 12;11:698537. doi: 10.3389/fonc.2021.698537. PMID: 34327139; PMCID: PMC8313436.

DOI

10.3389/fonc.2021.698537

ISSN

2234-943X

PubMed ID

34327139