Books and Book Chapters

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  Lymphoma

  Wakenda K. Tyler and Soheil Sabzevari

  Publication Date: 2-12-2025

  "Part of the popular Orthopaedic Knowledge Update® series, this comprehensive orthopaedic resource covers all aspects of the latest innovations in tumor care and optimized treatment in a single, convenient volume. Developed in partnership with the American Academy of Orthopaedic Surgeons (AAOS) and edited by Geoffrey W. Siegel, MD, FAAOS, and J. Sybil Biermann, MD, FAAOS, Orthopaedic Knowledge Update®: Musculoskeletal Tumors 5 reflects cutting-edge research and understanding of the molecular basis of neoplastic disease and optimized treatment options since the last volume published in 2020. Written and edited by leading orthopaedic surgeons and specialists, OKU®: Musculoskeletal Tumors 5 provides deep insight, real-world patient scenarios, and best practices supported by the latest evidence"-- Provided by publisher.

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  Clinical Laboratory Management

  Timothy C. Allen

  Publication Date: 3-25-2024

  Clinical Laboratory Management, Third Edition, edited by an esteemed team of professionals under the guidance of editor-in-chief Lynne S. Garcia, is a comprehensive and essential reference for managing the complexities of the modern clinical laboratory. This newly updated and reorganized edition addresses the fast-changing landscape of laboratory management, presenting both foundational insights and innovative strategies.

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  Pap Test, Pathology of the Cervix

  Vaishali Pansare

  Publication Date: 1-12-2024

  This encyclopedia volume covers the complete field of gynecologic pathology from Abnormal Villous Lesions to WHO Classification of Tumors of the Vulva. The alphabetically arranged entries, each of which provides a detailed description of a specific pathological disease pattern, allow readers to quickly and easily find the information they need.

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  Immunochemical Characterization of Immunglobulins in Serum, Urine , and Cerebrospinal Fluid

  Caitlin O. Schein and William G. Finn

  Publication Date: 12-24-2024

  For nearly 50 years, the Manual of Molecular and Clinical Laboratory Immunology has been the premier resource for laboratories, students, and professionals involved in the clinical and technical details of diagnostic immunology testing. The 9th Edition continues its tradition of providing comprehensive clinical and technical information on the latest technologies used in medical and diagnostic immunology.

  Led by a world-renowned group of authors and editors, this new edition reflects substantial changes aimed at improving and updating the Manual’s utility while reflecting the significant transformations that have occurred since the last edition, including the revolution of gene editing and the widespread adoption of molecularly engineered cellular therapies.

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  Evolving Understanding of Renal Progenitor (Stem) Cells in Renal Physiology and Pathophysiology

  Ping L. Zhang and Olaf Kroneman

  Publication Date: 3-24-2024

  In the embryonic kidney, the mesonephros functions transiently during early fetal development. By the second month, most disappear, but a few become gonad-associated components. The permanent kidney develops from the metanephros that contributes to the development of glomeruli, proximal tubules, and distal tubules under the induction of the ureteric bud generating the renal pelvis and collecting ducts. In the metanephros-associated kidneys, the parietal epithelial cells, as progenitor (stem) cells, stain positively for CD133 (a progenitor cell marker) and differentiate into visceral epithelial cells (also called podocytes). The podocytes then provide nutrients and paracrine factors to glomerular basement membranes, glomerular endothelium, and mesangial cells. Under some pathologic conditions, the parietal epithelial cells can either generate cellular crescents in the primary crescent glomerulonephritis or produce immature hyperplastic podocytes in the collapsing glomerulopathy. In normal proximal tubules, CD133-positive progenitor cells are scattered along the proximal tubules, particularly at the turning niche of each tubular segment. The tubular progenitor cells appear to serve as oxygen-sensing receptors related to the hypoxia-inducible factor-1α (HIF-1α)-associated oxygen-sensing system. Under hypoxic conditions, the tubular progenitor cells first spread their signals to the nearby tubular cells. Eventually, CD133-positive signals can be detected in all injured proximal tubular epithelial cells for regenerative repair. The chapter will provide readers with evolving understanding of where progenitor cells originate in the kidney, their roles in different renal diseases, and some potential directions for further research using renal progenitor cells.

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  The Biological Basis and Diagnostic Evaluation of Cancer

  Mark A. Micale, J Lynne Williams, Sumi Dinda, and Sara Rivard

  Publication Date: 2022

  • Coverage of physical therapy patient management includes acute care, outpatient, and multidisciplinary clinical settings, along with in-depth therapeutic management interventions.
  • Content on the continuum of cancer care addresses the primordial, primary, secondary, tertiary, and quaternary stages in prevention and treatment.
  • Focus on clinicians includes the professional roles, responsibilities, self-care, and values of the oncology rehabilitation clinician as an integral member of the cancer care team.

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  Use of Immunohistochemistry to Determine Expression of Rab5 Subfamily of GTPases in Mature and Developmental Brains

  Kwok Ling Kam, Paige Parrack, Marcellus Banworth, Sheeja Aravindan, Guangpu Li, and Kar Ming Fung

  Publication Date: 8-29-2021

  Rab GTPases are essentially molecular switches. They serve as master regulators in intracellular membrane trafficking from the formation and transport of vesicles at the originating organelle to its fusion to the membrane at the target organelle. Their functions are diversified and each has their specific subcellular location. Their expression may vary significantly in the same cell when the level of protein production is significantly different in different physiologic status. One of the best examples is the transition from fetal to mature status of cells. Expression and localization of Rab GTPases in mature and developing brains have not been well studied. Immunohistochemistry is an efficient way in the detection, semiquantitation, and localization of Rab GTPases in tissue sections. It is inexpensive and fast which allow efficient mass screening of many sections. In this chapter, we describe the immunohistochemical assay protocol for analyzing several Rab protein expressions of the Rab5 subfamily, including Rab5, Rab17, Rab22, and Rab31, in developmental (fetal) and mature human brains.

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  Cytology: Diagnostic Principles and Clinical Correlates

  Barbara S. Ducatman

  Publication Date: 2-21-2020

  Concise yet comprehensive, Cytology: Diagnostic Principles and Clinical Correlates is a practical guide to the diagnostic interpretation of virtually any cytological specimen you may encounter. This highly useful bench manual covers all organ systems and situations in which cytology is used, including gynecologic, non-gynecologic, and FNA samples, with an in-depth differential diagnosis discussion for all major entities. As with previous editions, the revised 5th Edition focuses on practical issues in diagnosis and the use of cytology in clinical care, making it ideal for both trainee and practicing pathologists.

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  Liver

  Barbara S. Ducatman and Kurt D. Bernacki

  Publication Date: 12-5-2019

  Fine-needle aspiration (FNA) and small core needle biopsy are mainstays in the evaluation of liver masses. They are usually performed percutaneously with guidance by computed tomography (CT), ultrasonography, or magnetic resonance imaging (MRI), and its principal value is in the diagnosis of malignancies. FNA can also be performed with the aid of endoscopic ultrasonography (EUS).

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  Graph Learning in Medical Imaging

  Junyan Wu, Jia-Xing Zhong, Eric Z. Chen, Jingwei Zhang, Jay J. Ye, and Limin Yu

  Publication Date: 11-14-2019

  Deep learning has been used to identify Basal Cell Carcinoma (BCC) from pathology images. The traditional patch-based strategy has the problem of integrating patch level information into the whole image level prediction. Also, it is often difficult to obtain sufficient high-quality patch labels such as pixel-wise segmentation masks. Benefiting from the recent development of Graph-CNN (GCN), we propose a new weakly- and semi-supervised GCN architecture to model patch-patch relation and provide patch-aware interpretability. Integrating prior knowledge and structure information, without relying on pixel-wise segmentation labels, our whole image level prediction achieves state-of-art performance with mAP 0.9556 and AUC 0.9502. Further visualization demonstrates that our model is implicitly consistent with the pixel-wise segmentation labels, which indicates our model can identify the region of interests without relying on the pixel-wise labels.