Impact of Pre-Procedural Red Cell Distribution Width on Long-Term Mortality Following Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-Analysis
Document Type
Conference Proceeding
Publication Date
5-2024
Publication Title
Journal of the Society for Cardiovascular Angiography & Interventions
Abstract
Background: Red cell distribution width (RDW) has emerged as a novel biomarker associated with adverse outcomes in patients with cardiovascular disease. We aimed to determine prognostic significance of pre-procedural RDW levels on long-term all-cause mortality following transcatheter aortic valve replacement (TAVR) by conducting a systematic review and meta-analysis due to limited evidence on impact of RDW levels in TAVR patients. Methods: We systematically reviewed articles on pre-procedural RDW and long-term ACM post-TAVR until December 2023 using PubMed, Google Scholar, Embase, and Scopus. Binary random effects model was used to calculate pooled adjusted odds ratio (aOR) and subgroup analysis was performed. I2 statistics were used to determine heterogeneity of studies. Leave one out sensitivity analysis was done to evaluate each study's effect on overall estimate and analysis robustness. Results: A total of 7 studies with 3486 patients aged between 70-90 years were included and > 55 % were females. High pre-procedural RDW was found to be an independent predictor of long-term ACM (aOR 1.86, 95% CI 1.38 - 2.51, p <0.01). This association is even more prominent when age < 80 years vs. > 80 years (aOR 2.05, 95% CI 1.45 -2.90, p <0.01 vs. aOR 1.75, 95% CI 1.20 - 2.55, p <0.01). When comparing pre-procedural RDW levels, we also found that higher levels were associated with increased odds of long-term ACM (aOR 1.93, 95% CI 1.53 - 2.43, p <0.01). Conclusions: Our study indicated that elevated baseline RDW is an independent predictor of long-term ACM post-TAVR. Further studies are needed
Volume
3
Issue
5 Suppl
First Page
18
Last Page
19
Recommended Citation
Pingili A, Kodali LSM, Vadiyala MR, Patel B, Zou Y, Balani PL, et al. [Ahmed H]. Impact of pre-procedural red cell distribution width on long-term mortality following transcatheter aortic valve replacement: a systematic review and meta-analysis. J Soc Cardiovasc Angiogr Interv. 2024 May;3(5 Suppl):18-19. doi: 10.1016/j.jscai.2024.101796
DOI
10.1016/j.jscai.2024.101796
Comments
Society for Cardiovascular Angiography & Interventions 2024 SCAI Scientific Sessions, May 2-4, 2024, Long Beach, CA