Impact of Pre-Procedural Brain Natriuretic Peptide Levels on Long-Term All-Cause Mortality and Cardiovascular Mortality Following Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-Analysis

Document Type

Conference Proceeding

Publication Date

5-2024

Publication Title

Journal of the Society for Cardiovascular Angiography & Interventions

Abstract

Background: Brain natriuretic peptide (BNP) is a well established prognostic marker in cardiovascular disease. However, evidence on its usefulness as a prognostic factor in patients undergoing transcatheter aortic valve replacement (TAVR) is limited. We conducted a systematic review and meta-analysis on impact of pre-procedural BNP on long-term all-cause mortality (ACM) and cardiovascular mortality (CVM) in patients undergoing TAVR. Methods: We systematically reviewed articles on pre-procedural BNP and post-TAVR long-term ACM and CVM until December 2023 using PubMed, Google Scholar, Embase, and Scopus. Binary random effects model was used to calculate pooled adjusted odds ratio (aOR) and subgroup analysis was performed. I2 statistics were used to determine heterogeneity of studies. Leave one out sensitivity analysis was done to evaluate each study's effect on overall estimate and analysis robustness. Results: A total of 4 studies with 3095 patients aged between 65-90 years were included, with over 55% being males. With a similar distribution of age, cardiovascular comorbidities, and echocardiographic characteristics, our study revealed higher odds of ACM (aOR 2.20, 95% CI 1.35 - 3.56, p

Volume

3

Issue

5 Suppl

First Page

19

Comments

Society for Cardiovascular Angiography & Interventions SCAI 2024 Scientific Sessions, May 2-24, 2024, Long Beach, CA

DOI

10.1016/j.jscai.2024.101797

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