Trends and Disparities of Cardiovascular Death in Breast Cancer: A Population-Based Retrospective Study in the United States From 1999 to 2020

Document Type

Conference Proceeding

Publication Date

4-2-2024

Publication Title

Journal of the American College of Cardiology

Abstract

Background: Breast cancer (Ca) patients are at increased risk of developing cardiovascular diseases, yet real-world cardiovascular mortality data among these patients remain limited. Methods: We queried the CDC WONDER database among adults aged ≥ 25 from 1999 to 2020. Cardiovascular disease was listed as the main cause of death, while breast Ca as contributing cause. We calculated age-adjusted mortality rates (AAMR) per 100,000 individuals and determined annual percent changes (APC) by using the Joinpoint regression program. Results: 74,733 breast Ca patients died of cardiovascular causes from 1999 to 2020. The overall AAMR decreased from 2.57 (95% CI, 2.50-2.65) in 1999 to 1.20 (95% CI, 1.15-1.24) in 2020 with an average APC of -4.3%. The three most common cardiovascular deaths were ischemic heart disease (47.8%), cerebrovascular disease (17.1%), and hypertensive disease (10.6%). Non-Hispanic African American patients constantly recorded the highest AAMR with an average of 1.95 (95% CI, 1.90-1.99), and Hispanic patients had the lowest AAMR with an average of 0.75 (95% CI, 0.72-0.78). A greater decrease in APC was seen in the older group ≥65 years old than in the younger group <65 years old (-4.39 [95% CI, -4.88- -3.91] vs. -2.91 [95% CI, -4.10 - -1.71]). The AAMR in rural regions and urban areas were comparable. Conclusion: The AAMR from cardiovascular deaths in breast Ca patients has decreased over past two decades. However, disparities in the AAMR across age groups, races, and regions were still present.

Volume

83

Issue

13 Suppl

First Page

2503

Comments

American College of Cardiology 73rd Annual Scientific Session & Expo, April 6-8, 2024, Atlanta, GA

DOI

10.1016/S0735-1097(24)04493-0

Link to Full Text

Share

COinS