Impact of Catheter Ablation for Atrial Fibrillation in Patients With Heart Failure With Preserved Ejection Fraction
Document Type
Conference Proceeding
Publication Date
5-2024
Publication Title
Heart Rhythm
Abstract
Background: The efficacy of catheter ablation as a treatment approach for patients with concurrent atrial fibrillation (AF) and heart failure with preserved ejection fraction (HFpEF) has been inadequately investigated. Objective: The objective of this study was to assess the effectiveness of AF catheter ablation in patients with heart failure with preserved ejection fraction. Methods: Utilizing the TriNetX research network, we identified individuals aged 18 and older with AF and HFpEF from January 1, 2010, to June 1, 2021. Patients were further classified based on their catheter ablation procedure, using Current Procedural Terminology codes. Following propensity-score matching, each cohort consisted of 9440 patients. The primary endpoint was all-cause mortality at 24 months and secondary outcomes during the 24-month follow-up encompassing readmissions for heart failure, AF, and stroke. Results: In the propensity-matched cohort, patients with AF and HFpEF who underwent catheter ablation had significantly lower all-cause mortality at 24 months than those who did not undergo AF catheter ablation (hazard ratio (HR): 0.37, 95% CI: 0.34-0.40; P ,0.001) even after matching antiarrhythmic medications. At 24 months, Secondary outcomes including HF readmissions (HR:0.86 95% CI: 0.84-0.89; P ,0.001) and stroke readmissions (HR: 0.66 95% CI: 0.59-0.73; P ,0.001) were lower in the AF catheter ablation group. Conclusion: Ablative intervention amongst AF patients with concomitant HFpEF showed a significant reduction in all-cause mortality. It also leads to significant reductions in readmissions due to HF and ischemic stroke at 24 months.
Volume
21
Issue
5S
First Page
S101
Last Page
S102
Recommended Citation
Patel H, Sheth A, Munshi RF, Patel B, Kumar A, Del Caprio Munoz F, et al. [Mehta N]. Impact of catheter ablation for arial fibrillation in patients with heart failure with preserved ejection fraction. Heart Rhythm. 2024 May;21(5S):S101-S102. doi:10.1016/j.hrthm.2024.03.467
DOI
10.1016/j.hrthm.2024.03.467
Comments
Heart Rhythm Society Annual Meeting, May 16-19, 2024, Boston, MA