Amniotic Bladder Therapy: Six-Month Follow Up Treating Interstitial Cystitis/Bladder Pain Syndrome.

Authors

Jack Considine
Kyle O'Hollaren
Codrut Radoiu
Raghav Madan
Aron Liaw, Corewell Health
Nivedita Dhar, Corewell Health

Document Type

Article

Publication Date

6-2024

Publication Title

Canadian Journal of Urology

Abstract

INTRODUCTION: Interstitial cystitis/bladder pain syndrome (IC/BPS) is characterized by chronic pelvic pain and usually accompanies lower urinary tract symptoms. We have previously reported that amniotic bladder therapy (ABT) provides symptomatic improvement in refractory IC/BPS patients for up to 3 months. Herein, we evaluated the durability of ABT up to 6 months.

MATERIALS AND METHODS: Consecutive IC/BPS patients received intra-detrusor injections of 100 mg micronized amniotic membrane. Clinical evaluation and patient-reported outcome measurements including Interstitial Cystitis Symptom Index (ICSI), Interstitial Cystitis Problem Index (ICPI), Bladder Pain/ Interstitial Cystitis Symptom Score (BPIC-SS) and Overactive Bladder Assessment Tool (OAB) were assessed.

RESULTS: Twenty-five consecutive recalcitrant IC/BPS patients were included in the study with an average age of 47.4 ± 14.4 years (29-67 years). After ABT, the IC/BPS symptoms improved gradually up to 3 months in all patients with an average improvement in ICSI, ICPI, BPIC-SS and OAB score of 72.8%, 71.9%, and 66.6%, (p < 0.001) respectively, at 3 months. At 4 months after ABT, 7 patients experienced a rebound in symptoms and requested another injection which resulted in a significant improvement in IC/BPS symptoms after 2, 4, and 8 weeks (p < 0.01). For the 18 patients who received only one injection, the IC/BPS symptoms were still significantly lower at 5 and 6 months compared to baseline (p < 0.01), suggesting a possible durable effect based on the ICSI, ICPI, BPIC-SS, and OAB questionnaire scores.

CONCLUSIONS: ABT provided an improvement in pain and lower urinary tract symptoms up to 6 months post-treatment in some refractory IC/BPS patients.

Volume

31

Issue

3

First Page

11898

Last Page

11903

Recommended Citation

Considine J, O'Hollaren K, Radoiu C, Madan R, Liaw A, Dhar N. Amniotic bladder therapy: six-month follow up treating interstitial cystitis/bladder pain syndrome. Can J Urol. 2024 Jun;31(3):11898-11903. PMID: 38912944.

ISSN

1195-9479

PubMed ID

38912944