A Diagnostic Test Combining Molecular Testing with Phenotypic Pooled Antibiotic Susceptibility Improved the Clinical Outcomes of Patients with Non-

Document Type

Article

Publication Date

5-1-2023

Publication Title

Res Rep Urol

Abstract

PURPOSE: Complicated UTIs (cUTIs) cause significant morbidity and healthcare resource utilization and cost. Standard urine culture has limitations in detecting polymicrobial and non-

METHODS: Patients who had symptoms typical of cUTI and positive M-PCR/P-AST test results were recruited from urology clinics. Symptom reduction and clinical cure rates were measured from day 0 through day 14 using the American English Acute Cystitis Symptom Score (ACSS) Questionnaire. Clinical cure was defined based on the sum of the scores of four US Food and Drug Administration (FDA) symptoms and the absence of visible blood in the urine.

RESULTS: Of 264 patients with suspected cUTI, 146 (55.4%) had exclusively non-

CONCLUSION: Patients with cUTIs treated based on the M-PCR/P-AST diagnostic test had significantly improved symptom reduction and clinical cure rates compared to untreated patients among those with non-

Volume

15

First Page

141

Last Page

147

DOI

10.2147/RRU.S404260

ISSN

2253-2447

PubMed ID

37151752

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