Paget's Presentation of High-Grade Ductal Carcinoma In Situ (DCIS) in a Very Young Female With Breast Cancer 2 (BRCA2) Mutation.
Document Type
Article
Publication Date
2-22-2024
Publication Title
Cureus
Abstract
This is a case of a previously healthy 29-year-old female with erythema and skin excoriations of the left breast nipple-areolar complex (NAC). After a repeat trial and failure of topical hydrocortisone, a diagnostic mammogram and nipple biopsy revealed Paget's disease (PD) of the nipple with ductal carcinoma in situ (DCIS). A subsequent genetic analysis found a breast cancer 2 (BRCA2) gene mutation. Treatment consisted of a left breast skin-sparing simple mastectomy with sentinel lymph node (SLN) biopsy and immediate tissue expander placement for implant reconstruction. Further management involved right breast short-interval surveillance with annual mammography and magnetic resonance imaging (MRI) with the possibility of prophylactic surgery along with oophorectomy after childbearing.
Volume
16
Issue
2
First Page
e54678
Recommended Citation
Butala S, Forestier C, Nithiananthan S, Defran AJ, Kuwajerwala NK. Paget's presentation of high-grade ductal carcinoma in situ (DCIS) in a very young female with breast cancer 2 (BRCA2) mutation. Cureus. 2024 Feb 22;16(2):e54678. doi: 10.7759/cureus.54678. PMID: 38524061.
DOI
10.7759/cureus.54678
ISSN
2168-8184
PubMed ID
38524061
