A Review of Melanoma Subtypes: Genetic and Treatment Considerations.
Document Type
Article
Publication Date
10-16-2024
Publication Title
Journal of surgical oncology
Abstract
Melanoma affects over one million people in the United States. This review explores genetic mutations and markers of all seven subtypes. Current treatment options and prognosis of each subtype are also discussed. For lentigo maligna, spitzoid, and nodular subtypes, BRAF was the most common mutation reported. For superficial spreading, TP53 was the most common. Acral lentiginous demonstrated CCDN1 and desmoplastic NF1 most frequently. No mutations have been identified in the nevoid subtype. Nodular melanoma is the deadliest subtype. Evidence suggests that the subtypes differ in regard to genetic markers/mutations, treatment and prognosis. Therefore, subtype should be considered when treating a melanoma patient.
Recommended Citation
Druskovich C, Kelley J, Aubrey J, Palladino L, Wright GP. A review of melanoma subtypes: genetic and treatment considerations. J Surg Oncol. 2024 Oct 16. doi: 10.1002/jso.27953. Epub ahead of print. PMID: 39415471.
DOI
10.1002/jso.27953
ISSN
1096-9098
PubMed ID
39415471