Effects of altered RTN3 expression on BACE1 activity and Alzheimer's neuritic plaques

Document Type

Article

Publication Date

2-1-2017

Publication Title

Reviews in the Neurosciences

Abstract

Reticulon 3 (RTN3), which is a member of the reticulon family of proteins, has a biochemical function of shaping tubular endoplasmic reticulum. RTN3 has also been found to interact with β-site amyloid precursor protein cleaving enzyme 1 (BACE1), which initiates the generation of β-amyloid peptides (Aβ) from amyloid precursor protein. Aβ is the major proteinaceous component in neuritic plaques, which constitute one of the major pathological features in brains of Alzheimer's disease (AD) patients. Mice deficient in or overexpressing RTN3 have altered amyloid deposition through effects on BACE1 expression and activity. In this review, we will summarize the current findings concerning the role of RTN3 in AD pathogenesis and demonstrate that RTN3 protein levels act as age-dependent modulators of BACE1 activity and Aβ deposition during the pathogenic progression of AD.

Volume

28

Issue

2

First Page

145

Last Page

154

DOI

10.1515/revneuro-2016-0054

ISSN

2191-0200

PubMed ID

27883331

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