Low Dose Brain Irradiation Reduces Amyloid-β and Tau in 3xTg-AD Mice.

Authors

George D Wilson, Beaumont Health
Thomas G Wilson, Beaumont Health
Alaa Hanna, Beaumont Health
Giovanni Fontanesi, Beaumont Health
Justin Kulchycki, Beaumont Health
Katie Buelow, Beaumont Health
Barbara L Pruetz, Beaumont Health
Daniel B Michael, Beaumont Health
Prakash Chinnaiyan, Beaumont Health
Michael E Maddens, Beaumont Health
Alvaro A Martinez, Beaumont Health
James Fontanesi, Beaumont Health

Document Type

Article

Publication Date

2020

Publication Title

Journal of Alzheimer's Disease : JAD

Abstract

We have previously reported that low doses of external beam ionizing irradiation reduced amyloid-β (Aβ) plaques and improved cognition in APP/PS1 mice. In this study we investigated the effects of radiation in an age-matched series of 3xTg-AD mice. Mice were hemibrain-irradiated with 5 fractions of 2 Gy and sacrificed 8 weeks after the end of treatment. Aβ and tau were assessed using immunohistochemistry and quantified using image analysis with Definiens Tissue Studio. We observed a significant reduction in Aβ plaque burden and tau staining; these two parameters were significantly correlated. This preliminary data is further support that low doses of radiation may be beneficial in Alzheimer's disease.

Volume

75

Issue

1

First Page

15

Last Page

21

Recommended Citation

Wilson GD, Wilson TG, Hanna A, Fontanesi G, Kulchycki J, Buelow K, Pruetz BL, Michael DB, Chinnaiyan P, Maddens ME, Martinez AA, Fontanesi J. Low Dose Brain Irradiation Reduces Amyloid-β and Tau in 3xTg-AD Mice. J Alzheimers Dis. 2020;75(1):15-21. doi: Wilson GD, Wilson TG, Hanna A, Fontanesi G, Kulchycki J, Buelow K, Pruetz BL, Michael DB, Chinnaiyan P, Maddens ME, Martinez AA, Fontanesi J. Low Dose Brain Irradiation Reduces Amyloid-β and Tau in 3xTg-AD Mice. J Alzheimers Dis. 2020;75(1):15-21. doi: 10.3233/JAD-200030. PMID: 32280098.. PMID: 32280098.

DOI

10.3233/JAD-200030

ISSN

1875-8908

PubMed ID

32280098