Diagnostic Biomarkers of Alzheimer's Disease as Identified in Saliva using 1H NMR-Based Metabolomics.
Document Type
Article
Publication Date
1-1-2017
Publication Title
Journal of Alzheimer's disease : JAD
Abstract
Using 1H NMR metabolomics, we biochemically profiled saliva samples collected from healthy-controls (n = 12), mild cognitive impairment (MCI) sufferers (n = 8), and Alzheimer's disease (AD) patients (n = 9). We accurately identified significant concentration changes in 22 metabolites in the saliva of MCI and AD patients compared to controls. This pilot study demonstrates the potential for using metabolomics and saliva for the early diagnosis of AD. Given the ease and convenience of collecting saliva, the development of accurate and sensitive salivary biomarkers would be ideal for screening those at greatest risk of developing AD.
Volume
58
Issue
2
First Page
355
Last Page
359
Recommended Citation
Yilmaz A, Geddes T, Han B, Bahado-Singh RO, Wilson GD, Imam K, Maddens M, Graham SF. Diagnostic Biomarkers of Alzheimer's Disease as Identified in Saliva using 1H NMR-Based Metabolomics. J Alzheimers Dis. 2017;58(2):355-359. doi: 10.3233/JAD-161226. PMID: 28453477.
DOI
10.3233/JAD-161226
ISSN
1875-8908
PubMed ID
28453477