Prognostic significance of MTOR expression in HPV positive and negative head and neck cancers treated by chemoradiation.

Document Type

Article

Publication Date

2-1-2020

Publication Title

Head & neck

Abstract

BACKGROUND: The mechanistic target of rapamycin (MTOR) plays a key role in regulating cell growth and metabolism and is commonly overexpressed in head and neck cancer (HNSCC). This study investigated the association of MTOR with clinical outcome in human papilloma virus (HPV) positive and negative HNSCC patients treated by chemoradiation.

METHODS: A tissue microarray (TMA) consisting of cores from 109 HNSCC patients treated by definitive chemoradiation was constructed and stained with antibodies against p16 and MTOR and expression correlated with clinicopathological features and clinical outcome.

RESULTS: MTOR varied widely between tumor cores and was not associated with HPV status or clinicopathological features. There was a positive correlation with pre-treatment FDG uptake. (P = .01). In HPV negative patients, MTOR predicted for shorter locoregional control (P = .02), diseases free survival (P = .02), and overall survival (P = .04). MTOR expression was not associated with outcome in HPV positive patients.

CONCLUSIONS: Prognostic significance of MTOR expression depends on HPV status.

Volume

42

Issue

2

First Page

153

Last Page

162

DOI

10.1002/hed.25983

ISSN

1097-0347

PubMed ID

31657099

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