Impaired Molecular Mechanisms Contributing to Chronic Pain in Patients with Hidradenitis Suppurativa: Exploring Potential Biomarkers and Therapeutic Targets.
Document Type
Article
Publication Date
1-25-2025
Publication Title
International journal of molecular sciences
Abstract
Hidradenitis suppurativa (HS) is a chronic skin condition that primarily affects areas with dense hair follicles and apocrine sweat glands, such as the underarms, groin, buttocks, and lower breasts. Intense pain and discomfort in HS have been commonly noted, primarily due to the lesions' effects on nearby tissues. Pain is a factor that can influence DNA methylation patterns, though its exact role in HS is not fully understood. We aim to identify molecular markers of chronic pain in HS patients. We performed DNA methylome of peripheral blood DNA derived from a group of 24 patients with HS and 24 healthy controls, using Illumina methylation array chips. We identified 253 significantly differentially methylated CpG sites across 253 distinct genes regulating pain sensitization in HS, including 224 hypomethylated and 29 hypermethylated sites. Several genes with pleiotropic roles include transporters (
Volume
26
Issue
3
First Page
1039
Recommended Citation
Radhakrishna U, Kuracha MR, Hamzavi I, Saiyed N, Prajapati J, Rawal RM et al Impaired molecular mechanisms contributing to chronic pain in patients with hidradenitis suppurativa: exploring potential biomarkers and therapeutic targets. Int J Mol Sci. 2025 Jan 25;26(3):1039. doi: 10.3390/ijms26031039. PMID: 39940809
DOI
10.3390/ijms26031039
ISSN
1422-0067
PubMed ID
39940809