Epigenetic and Metabolic Landscape of Dementia with Lewy Bodies.
Document Type
Article
Publication Date
12-30-2024
Publication Title
Movement disorders : official journal of the Movement Disorder Society
Abstract
BACKGROUND: Lewy body diseases, including dementia with Lewy bodies (DLB), are characterized by α-synuclein accumulation, leading to dementia. Previous studies suggest distinct epigenetic and metabolomic profiles in DLB.
OBJECTIVE: This study aims to identify diagnostic biomarkers by analyzing the methylome and metabolome in the Brodmann area 7 of postmortem brain tissues from DLB patients and control subjects using multiomics approaches.
METHODS: Methylation analysis was performed using the Illumina EPIC array, and metabolomics profiling was conducted via
RESULTS: We identified 3478 significantly differentially methylated cytosines, mostly hypermethylated, enriched in CpG islands near transcription start sites. Pathway enrichment analysis showed significant pathways, primarily linked to olfactory and synaptic functions. Metabolomics profiling identified 15 significantly altered metabolites, with Phosphatidylethanolamine (PE) Biosynthesis being the most affected pathway. Key correlations between differentially methylated cytosines and metabolites, particularly in the PE Biosynthesis pathway involving PTDSS1 and PCYT2 genes, were observed.
CONCLUSIONS: Notably, sex-specific differences were found, with females exhibiting more epigenetic and metabolomic changes than males. Increased hypermethylation, linked to transcriptional silencing, and disruptions in PE biosynthesis suggest a role in synaptic dysfunction and olfactory deficits. In addition, α-aminoadipic acid was strongly associated with vascular functions, hinting at a possible overlap between vascular health and DLB. This study provides new insights into DLB mechanisms and potential therapeutic targets. © 2024 International Parkinson and Movement Disorder Society.
Recommended Citation
Vishweswaraiah S, Yilmaz A, Gordevicius J, Milčiūtė M, Krinickis K, Kerseviciute I et al [Graham SF] Epigenetic and metabolic landscape of dementia with lewy bodies. Mov Disord. 2024 Dec 30. doi: 10.1002/mds.30095. Epub ahead of print. PMID: 39736077.
DOI
10.1002/mds.30095
ISSN
1531-8257
PubMed ID
39736077