Modeling bladder mechanics with 4D reconstruction of murine ex vivo bladder filling.
Document Type
Article
Publication Date
2-2025
Publication Title
Biomechanics and modeling in mechanobiology
Abstract
This study presents a novel methodology for high-resolution 3D bladder modeling during filling, developed by leveraging improved imaging and computational techniques. Using murine bladder filling data, the methodology generates accurate 3D geometries across time, enabling in-depth mechanical analysis. Comparison with a traditional spherical model revealed similar stress trends, but the 3D model permitted nuanced quantifications, such as localized surface curvature and stress analysis. This advanced 3D model captures complex tissue behavior crucially influenced by tissue-specific microstructural characteristics. This methodology can also be extended to other tissues such as lungs, uterus, and gastrointestinal tract tissues. Applying this analysis to different tissues can uncover mechanisms driven by localized mechanics, such as the sensation of fullness in the bladder due to microcontractions, uterine contractions during labor, and peristaltic contractions in the gastrointestinal tract. This broader applicability underscores our approach's potential to advance the understanding of tissue-specific mechanical behaviors across various biological systems.
Volume
24
Issue
1
First Page
347
Last Page
359
Recommended Citation
Broemer E, Saxena P, Bartolone S, Hennig G, Herrera GM, Zwaans B et al Modeling bladder mechanics with 4d reconstruction of murine ex vivo bladder filling. Biomech Model Mechanobiol. 2025 Feb;24(1):347-359. doi: 10.1007/s10237-024-01914-7. Epub 2024 Dec 31. PMID: 39741201.
DOI
10.1007/s10237-024-01914-7
ISSN
1617-7940
PubMed ID
39741201
