Accumulation of neutral lipids in dystrophic neurites surrounding amyloid plaques in Alzheimer's disease.

Document Type

Article

Publication Date

4-2024

Publication Title

Biochim Biophys Acta Mol Basis Dis

Abstract

Alzheimer's disease (AD) is characterized by the formation β-amyloid (Aβ) deposited neuritic plaques. Recent evidence suggests that abnormal lipid metabolism and accumulation could serve as biomarkers for neurodegenerative diseases, including AD. Tubular endoplasmic reticulum protein, reticulon 3 (RTN3), plays a crucial role in the development of neuritic plaque and lipid metabolism in AD brains. In present study, we sought to investigate a potential association between neutral lipid accumulation and AD pathology. BODIPY 500/510 dye was used to label neutral lipid surrounding Aβ plaques in APP

Volume

1870

Issue

4

First Page

167086

Last Page

167086

DOI

10.1016/j.bbadis.2024.167086

ISSN

1879-260X

PubMed ID

38378084

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