Accumulation of neutral lipids in dystrophic neurites surrounding amyloid plaques in Alzheimer's disease.

Authors

Hao Huang
Md Golam Sharoar, Corewell Health
Joseph Pathoulas
Liangliang Fan
Wanxia He
Rong Xiang
Riqiang Yan

Document Type

Article

Publication Date

4-2024

Publication Title

Biochim Biophys Acta Mol Basis Dis

Abstract

Alzheimer's disease (AD) is characterized by the formation β-amyloid (Aβ) deposited neuritic plaques. Recent evidence suggests that abnormal lipid metabolism and accumulation could serve as biomarkers for neurodegenerative diseases, including AD. Tubular endoplasmic reticulum protein, reticulon 3 (RTN3), plays a crucial role in the development of neuritic plaque and lipid metabolism in AD brains. In present study, we sought to investigate a potential association between neutral lipid accumulation and AD pathology. BODIPY 500/510 dye was used to label neutral lipid surrounding Aβ plaques in APP

Volume

1870

Issue

4

First Page

167086

Last Page

167086

Recommended Citation

Huang H, Sharoar MG, Pathoulas J, Fan L, He W, Xiang R, Yan R. Accumulation of neutral lipids in dystrophic neurites surrounding amyloid plaques in Alzheimer's disease. Biochim Biophys Acta Mol Basis Dis. 2024 Apr;1870(4):167086. doi: 10.1016/j.bbadis.2024.167086. Epub 2024 Feb 18. PMID: 38378084; PMCID: PMC10999334.

DOI

10.1016/j.bbadis.2024.167086

ISSN

1879-260X

PubMed ID

38378084