The Effect of Glycemic Control on Left Ventricular Function in Clinical and Experimental Diabetes.

Document Type

Article

Publication Date

7-7-2023

Publication Title

CJC Open

Abstract

BACKGROUND: Glycemic control in diabetes mellitus (DM) has not improved cardiovascular outcomes with normal left ventricular (LV) function. We assessed the effect on LV dysfunction using a canine model of LV dysfunction and DM, and in patients with DM and LV dysfunction.

METHODS: Chronic LV dysfunction was produced by coronary microsphere embolization in 34 canines (15-25 kg). Following 8 weeks of stabilization, DM was induced in 24 canines and randomized to good or poor glycemic control for 3 months. Ten canines without DM were controls. Hemodynamic and Doppler echocardiographic data were obtained prior to and following pressure loading. We reviewed the Doppler-echocardiography at baseline and follow-up in 207 patients with DM with reduced ejection fraction (EF; median follow-up = 612 days) and 60 age- and sex-matched non-DM patients with normal EF. Laboratory results, medications, and incident adverse events from medical records were obtained

RESULTS: EF = 43.8% ± 11.2% for all canines at 8 weeks. Canines with

CONCLUSIONS: Poor glycemic control had an adverse effect on preexisting LV dysfunction experimentally and in patients with type 2 diabetes.

Volume

5

Issue

10

First Page

728

Last Page

738

DOI

10.1016/j.cjco.2023.06.007

ISSN

2589-790X

PubMed ID

37876883

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