Bladder Detrusor Muscular Ring Size on Magnetic Resonance Imaging is Associated With Moderate and Severe American Urological Association Symptom Index Scores in Untreated Men With Benign Prostatic Hyperplasia - A Potential Novel Predictor of Lower Urinary Tract Symptoms

Authors

Kiran Nandalur, Beaumont Health
David Walker, Oakland University William Beaumont School of Medicine Medical Student
Hong Ye, Beaumont Health
Sayf Al-Katib, Beaumont Health
Brian Seifman, Beaumont Health
David Gangwish, Beaumont Health Resident
Abhay Dhaliwal, Beaumont Health Resident
Connor Ervin
Kayla Dobies
Channing Sesoko
Wesley Dejoie
Bernadette Zwaans, Beaumont Health
Sirisha Nandalur, Beaumont Health
Jennifer Nguyen, Oakland University William Beaumont School of Mediine Medical Student
Jason Hafron, Beaumont Health

Document Type

Conference Proceeding

Publication Date

4-2023

Publication Title

Journal of Urology

Abstract

INTRODUCTION AND OBJECTIVE: The etiology of lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia(BPH) remains uncertain. The purpose of our study was to quantitatively analyze anatomic characteristics on magnetic resonance imaging (MRI)to assess novel independent factors for LUTS. METHODS: This retrospective single-institution study evaluated treatment-naïve men who underwent prostate MRI within 3 months of American Urological Association Symptom Index (AUASI) scoring from June 2021 to September 2022. Factors measured on MRI included: size of the detrusor muscular ring (DMR) surrounding the bladder outlet, prostate volume, intravesicular prostate protrusion (IPP) volume, and prostate urethra angle (PUA). Multivariable logistic regression and ROC analysis were used to analyze factors for moderate/severe (AUASI≥8) and severe LUTS (AUASI≥20).RESULTS: 318 total men (mean age: 66.2 (SD:8.0)) were included: 31 with severe symptoms, 131 with moderate symptoms, and 156 with mild symptoms. Increasing age (p=0.02;OR:1.05(1.01-1.08)),PUA (p=0.02;OR:1.05(1.01-1.09), and DMR size measured as diameter (p<0.001;OR:5.6(3.37-9.16)) were significantly independently associated with AUASI≥8. For every one cm increase in DMR diameter, patients had approximately five times the odds for AUASI≥8. Increasing DMR size (diameter p<0.001;OR: 2.74 (1.76-4.27) was independently associated with severe symptoms. CONCLUSIONS: Expansion of the detrusor muscular ring surrounding the bladder outlet is a novel anatomic factor independently associated with moderate/severe LUTS. Prostate volume and IPP volume were unrelated to AUASI scoring.

Volume

209

Issue

4S

First Page

e317

Last Page

e318

Recommended Citation

Nandalur K, Walker D, Ye H, Al-Katib S, Seifman B, Gangwish D, et al. [Dhaliwal A, Zwaans B, Nandalur S, Nguygen J, Hafron J]. Bladder detrusor muscular ring size on magnetic resonance imaging is associated with moderate and severe American Urological Association symptom index scores in untreated men with benign prostatic hyperplasia - a potential novel predictor of lower urinary tract symptoms. J Urol. 2023 Apr;209(4S):e317-e318. doi:10.1097/JU.0000000000003249.03

Comments

American Urological Association Annual Meeting, April 28 - May 1, 2023, Chicago, IL

DOI

10.1097/JU.0000000000003249.03