A Case of Primary Peritoneal Adenocarcinoma: Diagnostic and Therapeutic Challenges.
Document Type
Article
Publication Date
4-12-2025
Publication Title
Cureus
Abstract
Primary peritoneal adenocarcinoma (PPA) is a rare and aggressive malignancy that closely resembles high-grade serous ovarian carcinoma but originates from the peritoneal lining with minimal ovarian involvement. We present the case of a 72-year-old female patient with a history of endometrial cancer who developed progressive ascites, recurrent hospitalizations, and a hypercoagulable state. Imaging revealed peritoneal carcinomatosis, and paracentesis confirmed high-grade serous carcinoma through immunohistochemical staining. Despite initial plans for chemotherapy, treatment was deferred for outpatient initiation. Due to disease progression, she underwent cytoreductive surgery with tumor debulking, but pathology confirmed metastatic spread. Postoperative complications included hypotension and ileus, which extended hospitalization. This case highlights the diagnostic and therapeutic challenges of PPA, emphasizing the need for a multidisciplinary approach to optimize patient outcomes.
Volume
17
Issue
4
First Page
e82140
Recommended Citation
Bitar I, Waggoner R, Alzayadi H, Abushaban K. A case of primary peritoneal adenocarcinoma: diagnostic and therapeutic challenges. Cureus. 2025 Apr 12;17(4):e82140. doi: 10.7759/cureus.82140. PMID: 40357085
DOI
10.7759/cureus.82140
ISSN
2168-8184
PubMed ID
40357085
