"Long-Term Outcomes Following Definitive or Adjuvant Proton Radiotherap" by Etzer Augustin, Adam L. Holtzman et al.
 

Long-Term Outcomes Following Definitive or Adjuvant Proton Radiotherapy for Adenoid Cystic Carcinoma.

Document Type

Article

Publication Date

4-24-2024

Publication Title

International Journal of Particle Therapy

Abstract

PURPOSE: Adenoid cystic carcinoma (ACC) is a rare malignancy accounting for 1% of all head and neck cancers. Treatment for ACC has its challenges and risks, yet few outcomes studies exist. We present long-term outcomes of patients with ACC of the head and neck treated with proton therapy (PT).

MATERIALS AND METHODS: Under an institutional review board-approved, single-institutional prospective outcomes registry, we reviewed the records of 56 patients with de novo, nonmetastatic ACC of the head and neck treated with PT with definitive (

RESULTS: With a median follow-up of 6.2 years (range, 0.9-14.7), the 5-year local-regional control (LRC), disease-free survival, cause-specific survival, and overall survival rates were 88%, 85%, 89%, and 89%, respectively. Intracranial extension (

CONCLUSION: This is the largest sample size with the longest median follow-up to date of patients with ACC treated with PT. PT can provide excellent disease control for ACC of the head and neck with acceptable toxicity. T4 disease, intracranial involvement, and gross residual disease at the time of PT following either biopsy or subtotal resection were significant prognostic features for worse outcomes.

Volume

11

First Page

100008

DOI

10.1016/j.ijpt.2024.100008

ISSN

2331-5180

PubMed ID

38757074

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