Duration of perioperative antibiotic prophylaxis in neonatal surgery: Less is more.

Document Type

Article

Publication Date

8-15-2024

Publication Title

American journal of surgery

Abstract

BACKGROUND: The ideal duration of neonatal antibiotic prophylaxis is not determined with wide variance in practice. This study aims to evaluate the association between duration of antibiotics and surgical site infection (SSI) in neonatal surgery.

METHODS: A retrospective review regarding antibiotic prophylaxis was performed on

RESULTS: 19/155 patients developed an SSI (12.26 %). Those with an SSI had a lower weight at surgery (p = 0.03). Additionally, wound classification (p = 0.17) and antibiotic duration >48hrs (p = 0.94) made no statistical difference in SSI rate. The two variables most closely linked to SSI development were gestational age (100 %) and weight at time of procedure (80.76 %).

CONCLUSIONS: Antibiotic prophylaxis >48 h did not decrease the incidence of SSI. Risk factors for SSI development in neonatal surgery were lower gestational age, decreased weight at time of procedure and total length of procedure.

First Page

115901

DOI

10.1016/j.amjsurg.2024.115901

ISSN

1879-1883

PubMed ID

39168743

Link to Full Text

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