Use of Colony-Stimulating Factors in Patients With Systemic Lupus Erythematosus.
Journal of pharmacy practice
Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease that commonly manifests as cutaneous rashes, renal disease, gastrointestinal dysfunction, and cytopenia. Hematological anomalies are frequently associated with drug-induced toxicity in SLE patients. Colony-stimulating factors have been used to treat drug-induced cytopenia in past case reports; however, evidence suggests that colony-stimulating factors can exacerbate autoimmune disorders, including SLE. This case report presents two patients with SLE exacerbations after colony-stimulating factor administration. The first case is a young male with SLE who developed pancytopenia with a white blood cell count (WBC) of 1 × 10
Ragsdale ME, Hall Zimmerman LG. Use of colony-stimulating factors in patients with systemic lupus erythematosus. J Pharm Pract. 2023 Jun;36(3):719-724. doi: 10.1177/08971900211053268. PMID: 34748466.