Title
Management of severe hyperbilirubinemia in the cholestatic neonate: a review and an approach.
Document Type
Article
Publication Date
2-10-2022
Publication Title
Journal of perinatology : official journal of the California Perinatal Association
Abstract
A review of the literature demonstrates that severe total hyperbilirubinemia (total serum bilirubin ≥ 20 mg/dL [340 µmol/L]) in some cholestatic term (≥37 weeks) and late-preterm (≥340/7-366/7 weeks) gestation neonates poses a risk for bilirubin-induced brain damage. When the direct bilirubin fraction is <50% of the total serum bilirubin this risk is associated with the total serum bilirubin alone and treatment decisions should be based on the total serum bilirubin. On the other hand, there are limited data on the risk of bilirubin-induced brain damage in the neonate with severe total hyperbilirubinemia and a direct bilirubin fraction that is equal to or exceeds 50% of the total serum bilirubin. When this rare combination occurs, efforts to keep the indirect bilirubin fraction from reaching severe levels might, nevertheless, be prudent.
Volume
Online ahead of print.
Recommended Citation
Watchko JF, Maisels MJ. Management of severe hyperbilirubinemia in the cholestatic neonate: a review and an approach. J Perinatol. 2022 Feb 10. doi: 10.1038/s41372-022-01330-8. Epub ahead of print. PMID: 35145210.
DOI
10.1038/s41372-022-01330-8
ISSN
1476-5543
PubMed ID
35145210