Identification of Aggressive Variants of Mantle Cell Lymphoma Based on Flow Cytometry

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Authors

Alan Nguyen, Oakland University William Beaumont School of Medicine Medical Student
Alia Gupta, Beaumont Health
Marc Smith, Beaumont Health
James Huang, Beaumont Health

Description

INTRODUCTION
Mantle cell lymphoma (MCL) is a rare subtype of B-cell non-Hodgkin lymphoma characterized by a (1,14) translocation resulting in overexpression of cyclin D1.1 MCL variants and a heterogenous disease presentation make this a challenging diagnosis with a highly variable outcome. Pleomorphic and blastic variants have an aggressive clinical course and shorter survival than the classical type.2 The pleomorphic variant shows a marked variation in nuclear size, shape, and mitotic index.3 The blastic variant appears small and immature with fine chromatin mimicking acute leukemia.3 The aim of our study is to explore if flow cytometry analysis can help with the identification of aggressive MCL variants.

Publication Date

5-2-2022

Keywords

mantle cell lymphoma, cytometry

Disciplines

Pathology

Recommended Citation

Nguyen A, Gupta A, Smith M, Huang J. Identification of aggressive variants of mantle cell lymphoma based on flow cytometry. Poster presented at: Oakland University William Beaumont School of Medicine Embark Capstone Colloquium; 2022 May 2; Rochester Hills, MI.

Comments

The Embark Capstone Colloquium at the Oakland University William Beaumont School of Medicine, Rochester Hills, MI, May 2, 2022.