Document Type

Conference Proceeding

Publication Date

9-2023

Publication Title

Archives of Pathology & Laboratory Medicine

Abstract

Context: The prevalence of renal tumors arising from adult polycystic kidney disease (APKD) has been rarely reported in the pathology literature. We report our findings of various renal tumors in APKD nephrectomy specimens.

Design: We searched our database for APKD during the past 11 years and identified various primary malignant tumors within the kidneys of APKD.

Results: Forty-eight nephrectomies with APKD were evaluated. Ten malignant tumors were identified in the APKD kidneys, indicating a prevalence of 20.8% (10/48; Table). These included 4 clear cell (CC) renal cell carcinomas (RCCs) ranging from 1 mm to 6.7 cm, 3 papillary RCCs (2.5, 3.5, and 14 cm with lymph node metastasis), 1 acquired cystic disease (ACD)–associated RCC (4 mm), 1 clear cell papillary (CCP) renal cell tumor (RCT), and 1 urothelial adenocarcinoma. The urothelial adenocarcinoma was found near a tubulovillous adenoma in a collecting duct and stained positively for GATA3 and uroplakin-2 but was negative for PAX8 and CDX2. The tumor showed extensive invasion to perirenal fatty tissue and duodenum.

Conclusions: Our data show a prevalence of renal tumors at 20.8% in the APKD kidneys, higher than a previous report (12.4%, 11/89; Hajj et al, Urology, 2009). Renal tumors were mostly from damaged proximal tubular primary (clear cell or papillary RCC) but can be derived from distal tubular or urothelial primary as well

Volume

147

Issue

9

First Page

e64

Comments

College of American Pathologists 2023 Annual Meeting CAP23, October 7-10, 2023, Chicago, IL

Last Page

e65

DOI

10.5858/arpa.2023-0258-AB

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