Document Type

Conference Proceeding

Publication Date

9-2022

Publication Title

Archives of Pathology & Laboratory Medicine

Abstract

Context: C3GNs represent a rare type of glomerulopathy due to the activation of alternative complement pathway, including C3-dominant glomerulonephritis (C3D-GN) and dense deposit disease (DDD). The goal of this study was to demonstrate a spectrum of C3GNs.

Design: The study searched 3165 renal biopsies to identify C3GNs and their clinical indices over an 8-year period.

Conclusions: Our data indicate that C3GN cases had a consistent finding of dominant C3 staining, and low serum C3 in most, but exhibited a wide range of clinical and pathologic changes in pediatric to elderly patients. The findings support the previously reported characteristics of C3GN.

Results: Thirteen C3GNs out of 3165 biopsies (0.41%) were identified, including 11 C3D-GNs and 2 DDD, with 7 female and 6 male patients (Table). The median age was 44 years (ranging from 5 to 69). The average urine protein to creatinine ratio was 4.09 mg/mg (ranging from 1.1 to 21). The median serum creatinine (sCr) was 4.06 mg/dL (ranging from 1.10 to 9.09). All patients with C3/C4 levels showed normal (N) C4 levels and 78% showed low C3 levels. Light microscopy ranged from mesangial proliferative pattern to membranoproliferative pattern. Immunofluorescent stains were consistent with dominant 2+ to 3+ stronger C3 staining than other stains. Electron microscopy ranged from mesangial deposits to subendothelial deposits or ribbon type of intramembranous deposits in DDD.

Volume

146

Issue

9

First Page

e89

Comments

College of American Pathologists 2022 Annual Meeting (CAP22), October 8-11, 2022, New Orleans, LA.

Last Page

e90

DOI

10.5858/arpa.2022-0231-AB

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