Document Type

Conference Proceeding

Publication Date

9-2022

Publication Title

Archives of Pathology & Laboratory Medicine

Abstract

Context: COVID-19 has been shown to cause renal pathology by multiple proposed mechanisms. However, studies evaluating renal biopsies for the effects of COVID-19 remain limited. We report our experience in our health system in a variety of renal pathologic diagnoses caused by COVID-19 infection.

Design: We performed detailed analysis of 5 renal biopsies related to COVID-19 infection, of 812 renal biopsies over the previous 22 months (0.6% of all cases).

Results: The first 3 patients were 2 African American men, 34 and 45 years old, and 1 48-year-old white male transplant recipient who developed acute kidney injury and nephrotic range of proteinuria after COVID-19 infections. Renal biopsies showed collapsing glomerulopathies in the patients. Patient 4, a 71-year-old white woman, developed acute kidney injury (serum creatinine at 5.56 mg/dL) with hematuria and proteinuria following COVID-19 infection. Her renal biopsy revealed moderate acute tubular necrosis and mild IgA nephropathy. Patient 5, a 15-year-old African American adolescent girl infected with COVID-19, developed nephrotic range proteinuria, which became negative soon after the renal biopsy. The renal biopsy revealed segmental fusion of foot processes compatible with minimal-change disease in remission.

Conclusions: The results of our 5 patients with COVID-19 infection included 3 collapsing glomerulopathies, 1 IgA nephropathy/acute tubular necrosis, and 1 minimal-change disease in remission, supporting previous reported varieties of renal diseases due to COVID-19 infection.

Volume

146

Issue

9

First Page

e83

Comments

College of American Pathologists 2022 Annual Meeting (CAP22), October 8-11, 2022, New Orleans, LA.

DOI

10.5858/arpa.2022-0231-AB

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