MDS with 5q deletion and rare cKIT positive mastocytosis: a diagnostic and therapeutic challenge

Authors

Daniel Steven Sanders
Thomas Fennell, Beaumont Health
Mohammad Muhsin Chisti, Beaumont Health

Document Type

Article

Publication Date

4-20-2019

Publication Title

BMJ case reports

Abstract

A patient with a diagnosis of myelodysplastic syndrome (MDS) with isolated 5q deletion underwent repeat bone marrow biopsy to assess haematological response after 6 months of initial lenalidomide therapy. Subsequent bone marrow biopsies revealed persistent MDS with del(5q) in addition to a small atypical mast cell population with >25% of mast cells with spindle-shaped morphology and immunohistochemistry characteristics consistent with mastocytosis. Molecular testing on the bone marrow was positive for

Volume

12

Issue

4

First Page

e227768

Recommended Citation

Sanders DS, Fennell T, Chisti MM. MDS with 5q deletion and rare cKIT positive mastocytosis: a diagnostic and therapeutic challenge. BMJ Case Rep. 2019 Apr 20;12(4):e227768. doi: 10.1136/bcr-2018-227768. PMID: 31005862; PMCID: PMC6506002.

DOI

10.1136/bcr-2018-227768

ISSN

1757-790X

PubMed ID

31005862