MDS with 5q deletion and rare cKIT positive mastocytosis: a diagnostic and therapeutic challenge
Document Type
Article
Publication Date
4-20-2019
Publication Title
BMJ case reports
Abstract
A patient with a diagnosis of myelodysplastic syndrome (MDS) with isolated 5q deletion underwent repeat bone marrow biopsy to assess haematological response after 6 months of initial lenalidomide therapy. Subsequent bone marrow biopsies revealed persistent MDS with del(5q) in addition to a small atypical mast cell population with >25% of mast cells with spindle-shaped morphology and immunohistochemistry characteristics consistent with mastocytosis. Molecular testing on the bone marrow was positive for
Volume
12
Issue
4
First Page
e227768
Recommended Citation
Sanders DS, Fennell T, Chisti MM. MDS with 5q deletion and rare cKIT positive mastocytosis: a diagnostic and therapeutic challenge. BMJ Case Rep. 2019 Apr 20;12(4):e227768. doi: 10.1136/bcr-2018-227768. PMID: 31005862; PMCID: PMC6506002.
DOI
10.1136/bcr-2018-227768
ISSN
1757-790X
PubMed ID
31005862
