cGAS-mediated autophagy protects the liver from ischemia-reperfusion injury independently of STING.

Document Type

Article

Publication Date

6-1-2018

Publication Title

American journal of physiology. Gastrointestinal and liver physiology

Abstract

Liver ischemia-reperfusion (I/R) injury occurs through induction of oxidative stress and release of damage-associated molecular patterns (DAMPs), including cytosolic DNA released from dysfunctional mitochondria or from the nucleus. Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) is a cytosolic DNA sensor known to trigger stimulator of interferon genes (STING) and downstream type 1 interferon (IFN-I) pathways, which are pivotal innate immune system responses to pathogen. However, little is known about the role of cGAS/STING in liver I/R injury. We subjected C57BL/6 (WT), cGAS knockout (cGAS

Volume

314

Issue

6

First Page

G655

Last Page

G667

DOI

doi: 10.1152/ajpgi.00326.2017

ISSN

1522-1547

PubMed ID

29446653

Share

COinS