cGAS-mediated autophagy protects the liver from ischemia-reperfusion injury independently of STING.
Document Type
Article
Publication Date
6-1-2018
Publication Title
American journal of physiology. Gastrointestinal and liver physiology
Abstract
Liver ischemia-reperfusion (I/R) injury occurs through induction of oxidative stress and release of damage-associated molecular patterns (DAMPs), including cytosolic DNA released from dysfunctional mitochondria or from the nucleus. Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) is a cytosolic DNA sensor known to trigger stimulator of interferon genes (STING) and downstream type 1 interferon (IFN-I) pathways, which are pivotal innate immune system responses to pathogen. However, little is known about the role of cGAS/STING in liver I/R injury. We subjected C57BL/6 (WT), cGAS knockout (cGAS
Volume
314
Issue
6
First Page
G655
Last Page
G667
Recommended Citation
Lei Z, Deng M, Yi Z, Sun Q, Shapiro RA, Xu H, Li T, Loughran PA, Griepentrog JE, Huang H, Scott MJ, Huang F, Billiar TR. cGAS-mediated autophagy protects the liver from ischemia-reperfusion injury independently of STING. Am J Physiol Gastrointest Liver Physiol. 2018 Jun 1;314(6):G655-G667. doi: 10.1152/ajpgi.00326.2017. Epub 2018 Feb 15. PMID: 29446653; PMCID: PMC6032062.
DOI
doi: 10.1152/ajpgi.00326.2017
ISSN
1522-1547
PubMed ID
29446653