Detection of IL12/23p40 via PET Visualizes Inflammatory Bowel Disease.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Inflammatory bowel disease (IBD), which includes both Crohn disease and ulcerative colitis, is a relapsing inflammatory disease of the gastrointestinal tract. Long-term chronic inflammatory conditions elevate the patient's risk of colorectal cancer (CRC). Currently, diagnosis requires endoscopy with biopsy. This procedure is invasive and requires a bowel-preparatory regimen, adding to patient burden. Interleukin 12 (IL12) and interleukin 23 (IL23) play key roles in inflammation, especially in the pathogenesis of IBD, and are established therapeutic targets. We propose that imaging of IL12/23 and its p40 subunit in IBD via immuno-PET potentially provides a new noninvasive diagnostic approach.
Rezazadeh F, Ramos N, Saliganan AD, Al-Hallak N, Chen K, Mohamad B, et al [Wiesend WN] Detection of IL12/23p40 via PET visualizes inflammatory bowel disease. J Nucl Med. 2023 Jul 20:jnumed.123.265649. doi: 10.2967/jnumed.123.265649. Epub ahead of print. PMID: 37474270.