Detection of IL12/23p40 via PET Visualizes Inflammatory Bowel Disease.
Document Type
Article
Publication Date
7-20-2023
Publication Title
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Abstract
Inflammatory bowel disease (IBD), which includes both Crohn disease and ulcerative colitis, is a relapsing inflammatory disease of the gastrointestinal tract. Long-term chronic inflammatory conditions elevate the patient's risk of colorectal cancer (CRC). Currently, diagnosis requires endoscopy with biopsy. This procedure is invasive and requires a bowel-preparatory regimen, adding to patient burden. Interleukin 12 (IL12) and interleukin 23 (IL23) play key roles in inflammation, especially in the pathogenesis of IBD, and are established therapeutic targets. We propose that imaging of IL12/23 and its p40 subunit in IBD via immuno-PET potentially provides a new noninvasive diagnostic approach.
Volume
jnumed.123.265649
Recommended Citation
Rezazadeh F, Ramos N, Saliganan AD, Al-Hallak N, Chen K, Mohamad B, et al [Wiesend WN] Detection of IL12/23p40 via PET visualizes inflammatory bowel disease. J Nucl Med. 2023 Jul 20:jnumed.123.265649. doi: 10.2967/jnumed.123.265649. Epub ahead of print. PMID: 37474270.
DOI
10.2967/jnumed.123.265649
ISSN
1535-5667
PubMed ID
37474270