BET inhibition increases βIII-tubulin expression and sensitizes metastatic breast cancer in the brain to vinorelbine.

Authors

Deepak Kanojia
Wojciech K Panek
Alex Cordero
Jawad Fares
Annie Xiao
Solomiia Savchuk
Krishan Kumar
Ting Xiao
Katarzyna C Pituch
Jason Miska
Peng Zhang
Kwok Ling Kam, Beaumont Health
Craig Horbinski
Irina V Balyasnikova
Atique U Ahmed
Maciej S Lesniak

Document Type

Article

Publication Date

8-26-2020

Publication Title

Science translational medicine

Abstract

Metastases from primary breast cancer result in poor survival. βIII-tubulin (TUBB3) has been established as a therapeutic target for breast cancer metastases specifically to the brain. In this study, we conducted a systematic analysis to determine the regulation of

Volume

12

Issue

558

First Page

eaax2879

Recommended Citation

Kanojia D, Panek WK, Cordero A, Fares J, Xiao A, Savchuk S, Kumar K, Xiao T, Pituch KC, Miska J, Zhang P, Kam KL, Horbinski C, Balyasnikova IV, Ahmed AU, Lesniak MS. BET inhibition increases βIII-tubulin expression and sensitizes metastatic breast cancer in the brain to vinorelbine. Sci Transl Med. 2020 Aug 26;12(558):eaax2879. doi: 10.1126/scitranslmed.aax2879. PMID: 32848091; PMCID: PMC8276250.

DOI

10.1126/scitranslmed.aax2879

ISSN

1946-6242

PubMed ID

32848091