Using methylation profiling to diagnose systemic metastases of pleomorphic xanthoastrocytoma.

Document Type

Article

Publication Date

1-2020

Publication Title

Neuro-oncology advances

Abstract

New methods of molecular testing are improving diagnostic accuracy and reliability beyond what the traditional light microscope can provide. In the current case, methylome profiling and next-generation sequencing were used to prove that tumors in the chest wall and spine were metastases from what, by histology, appeared to be a low-grade cerebral glioma. They also identified a targetable BRAF V600E mutation that dictated subsequent therapy, to which the patient responded.

Volume

2

Issue

1

First Page

vdz057

DOI

10.1093/noajnl/vdz057

ISSN

2632-2498

PubMed ID

32002518

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