New-onset postpartum preeclampsia: epigenetic mechanism and prediction.

Document Type

Article

Publication Date

12-2022

Publication Title

Journal of Maternal-Fetal & Neonatal Medicine

Abstract

OBJECTIVE: Placental cytosine (CpG) methylation was measured to predict new-onset postpartum preeclampsia (NOPP) and interrogate its molecular pathogenesis.

METHODS: NOPP was defined as patients with a new diagnosis of postpartum preeclampsia developing ≥48 h to ≤6 weeks after delivery with no prior hypertensive disorders. Placental tissue was obtained from 12 NOPP cases and 12 normotensive controls. Genome-wide individual cytosine (CpG) methylation level was measured with the Infinium MethylationEPIC BeadChip array. Significant differential methylation (NOPP vs. controls) for individual CpG loci was defined as false discovery rate (FDR)

RESULTS: There were 537 (in 540 separate genes) significantly (FDR

CONCLUSIONS: There was significant placental epigenetic dysregulation in NOPP. NOPP shared both common and unique molecular pathways with classic preeclampsia. Finally, we have identified novel potential biomarkers for the early post-partum prediction of NOPP.

Volume

35

Issue

25

First Page

7179

Last Page

7187

DOI

10.1080/14767058.2021

ISSN

1476-4954

PubMed ID

34374309

Link to Full Text

Share

COinS