3D-Printed Ceramic-Demineralized Bone Matrix Hyperelastic Bone Composite Scaffolds for Spinal Fusion.
Document Type
Article
Publication Date
2-1-2020
Publication Title
Tissue Engineering Part A
Abstract
Although numerous spinal biologics are commercially available, a cost-effective and safe bone graft substitute material for spine fusion has yet to be proven. In this study, "3D-Paints" containing varying volumetric ratios of hydroxyapatite (HA) and human demineralized bone matrix (DBM) in a poly(lactide-co-glycolide) elastomer were three-dimensional (3D) printed into scaffolds to promote osteointegration in rats, with an end goal of spine fusion without the need for recombinant growth factor. Spine fusion was evaluated by manual palpation, and osteointegration and
Volume
26
Issue
3-4
First Page
157
Last Page
166
Recommended Citation
Driscoll JA, Lubbe R, Jakus AE, Chang K, Haleem M, Yun C, Singh G, Schneider AD, Katchko KM, Soriano C, Newton M, Maerz T, Li X, Baker K, Hsu WK, Shah RN, Stock SR, Hsu EL. 3D-Printed Ceramic-Demineralized Bone Matrix Hyperelastic Bone Composite Scaffolds for Spinal Fusion. Tissue Eng Part A. 2020 Feb;26(3-4):157-166. doi: 10.1089/ten.TEA.2019.0166. Epub 2019 Sep 26. PMID: 31469055; PMCID: PMC7044791.
DOI
10.1089/ten.TEA.2019.0166
ISSN
1937-335X
PubMed ID
31469055