A Unique Presentation of Levamisole-Induced Antineutrophil- Cytoplasmic-Antibody-Positive Vasculitis Presenting as Inflammatory Orbitopathy.

Authors

Hannah M Muniz Castro
Thai H Do, Beaumont Health
Meenakshi B Bhattacharjee
Ore-Ofe O Adesina
Karina Richani

Document Type

Article

Publication Date

7-1-2020

Publication Title

Ophthalmic Plastic and Reconstructive Surgery

Abstract

A 35-year-old woman with a history of cocaine abuse presented with progressively worsening OS pain. Neuroimaging revealed a 3-cm ill-defined left orbital lesion involving the intraconal and extraconal spaces. The orbital mass was biopsied via an anterior orbitotomy approach. Pathology demonstrated prominent angiocentric granulomatous and lymphoplasmacytic inflammation consistent with vasculitis. Laboratory tests were significant for neutropenia, positive perinuclear antineutrophil cytoplasmic antibodies with high titer, and positive myeloperoxidase antibodies, consistent with levamisole-induced vasculitis. To the authors' knowledge, this is the first reported case of cocaine-levamisole-induced vasculitis presenting as orbitopathy.

Volume

36

Issue

4

First Page

96

Last Page

100

Recommended Citation

Muniz Castro HM, Do TH, Bhattacharjee MB, Adesina OO, Richani K. A Unique Presentation of Levamisole-Induced Antineutrophil- Cytoplasmic-Antibody-Positive Vasculitis Presenting as Inflammatory Orbitopathy. Ophthalmic Plast Reconstr Surg. 2020 Jul/Aug;36(4):e96-e100. doi: 10.1097/IOP.0000000000001612. PMID: 32221103.

DOI

10.1097/IOP.0000000000001612

ISSN

1537-2677

PubMed ID

32221103