Evaluating COVID-19 Vaccine Effectiveness During Pre-Delta, Delta and Omicron Dominant Periods Among Pregnant People in the U.S.: Retrospective Cohort Analysis From a Nationally Sampled Cohort in National COVID Collaborative Cohort (N3C).
Document Type
Article
Publication Date
7-2024
Publication Title
BMJ Public Health
Abstract
OBJECTIVES: To evaluate the effectiveness of COVID-19 vaccinations (initial and booster) during pre-Delta, Delta, and Omicron dominant periods among pregnant people via (1) COVID-19 incident and severe infections among pregnant people who were vaccinated vs. unvaccinated and (2) post-COVID-19 vaccination breakthrough infections and severe infections among vaccinated females who were pregnant vs. non-pregnant.
DESIGN: Retrospective cohort study using nationally sampled electronic health records data from the National COVID Cohort Collaborative (N3C), December 10, 2020, to June 07, 2022.
PARTICIPANTS: Cohort 1 included pregnant people (15-55 years), and Cohort 2 included vaccinated females of reproductive age (15-55 years).
EXPOSURES: (1) COVID-19 vaccination and (2) pregnancy.
MAIN OUTCOME MEASURES: Adjusted hazard ratios (aHRs) for COVID-19 incident or breakthrough infections and severe infections (i.e., COVID-19 infections with related hospitalizations).
RESULTS: In Cohort 1, 301,107 pregnant people were included. Compared to unvaccinated pregnant people, the aHRs for pregnant people with initial vaccinations
CONCLUSIONS: Pregnant people with initial and booster vaccinations during pregnancy had a lower risk of incident and severe COVID-19 infections compared to unvaccinated pregnant people across the pandemic stages. However, vaccinated pregnant people still had a higher risk of severe infections compared to non-pregnant females.
Volume
2
Issue
1
First Page
e000770
Recommended Citation
Qin QC, Wilkins KJ, Jones SE, Bradwell KR, Chan LE, Sun J, et al. [Mariona F]. Evaluating COVID-19 vaccine effectiveness during pre-Delta, Delta and Omicron dominant periods among pregnant people in the U.S.: Retrospective cohort analysis from a nationally sampled cohort in National COVID Collaborative Cohort (N3C). BMJ Public Health. 2024 Jul;2(1):e000770. doi: 10.1136/bmjph-2023-000770. PMID: 39363958.
DOI
10.1136/bmjph-2023-000770
ISSN
2753-4294
PubMed ID
39363958
