Untargeted Metabolomic Biomarker Discovery for the Detection of Ectopic Pregnancy.

Authors

Onur Turkoglu, Corewell Health Fellow
Ayse Citil
Ceren Katar
Ismail Mert
Robert A Quinn
Ray O. Bahado-Singh, Corewell Health
Stewart F. Graham, Corewell Health

Document Type

Article

Publication Date

9-26-2024

Publication Title

International journal of molecular sciences

Abstract

Ectopic pregnancy (EP) is the leading cause of maternal morbidity and mortality in the first trimester. Using an untargeted metabolomic approach, we sought to identify putative plasma biomarkers using tandem liquid chromatography-mass spectrometry for the detection of tubal EP. This case-control study included the prospective recruitment of 50 tubal EP cases and 50 early intrauterine pregnancy controls. To avoid over-fitting, logistic regression models were developed in a randomly selected discovery group (30 cases vs. 30 controls) and validated in the test group (20 cases vs. 20 controls). In total, 585 mass spectral features were detected, of which 221 molecular features were significantly altered in EP plasma (

Volume

25

Issue

19

First Page

10333

Recommended Citation

Turkoglu O, Citil A, Katar C, Mert I, Quinn RA, Bahado-Singh RO, et al [Graham SF] Untargeted metabolomic biomarker discovery for the detection of ectopic pregnancy. Int J Mol Sci. 2024 Sep 26;25(19):10333. doi: 10.3390/ijms251910333. PMID: 39408663.

DOI

10.3390/ijms251910333

ISSN

1422-0067

PubMed ID

39408663