The longitudinal biochemical profiling of TBI in a drop weight model of TBI.
Document Type
Article
Publication Date
12-14-2023
Publication Title
Scientific reports
Abstract
Traumatic brain injury (TBI) is a major cause of mortality and disability worldwide, particularly among individuals under the age of 45. It is a complex, and heterogeneous disease with a multifaceted pathophysiology that remains to be elucidated. Metabolomics has the potential to identify metabolic pathways and unique biochemical profiles associated with TBI. Herein, we employed a longitudinal metabolomics approach to study TBI in a weight drop mouse model to reveal metabolic changes associated with TBI pathogenesis, severity, and secondary injury. Using proton nuclear magnetic resonance (
Volume
13
Issue
1
First Page
22260
Recommended Citation
Yilmaz A, Liraz-Zaltsman S, Shohami E, Gordevičius J, Kerševičiūtė I, Sherman E, et al [Bahado-Singh RO, Graham SF] The longitudinal biochemical profiling of TBI in a drop weight model of TBI. Sci Rep. 2023 Dec 14;13(1):22260. doi: 10.1038/s41598-023-48539-x. PMID: 38097614
DOI
10.1038/s41598-023-48539-x
ISSN
2045-2322
PubMed ID
38097614